29 Result(s)
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Christopher R. K. Ching
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Article
Open AccessEffects of gene dosage and development on subcortical nuclei volumes in individuals with 22q11.2 copy number variations
The 22q11.2 locus contains genes critical for brain development. Reciprocal Copy Number Variations (CNVs) at this locus impact risk for neurodevelopmental and psychiatric disorders. Both 22q11.2 deletions (22q...
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Chapter
Large-Scale Neuroimaging of Mental Illness
Neuroimaging has provided important insights into the brain variations related to mental illness. Inconsistencies in prior studies, however, call for methods that lead to more replicable and generalizable brai...
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Article
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to det...
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Article
Open AccessMulti-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures
Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing alg...
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Article
Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological app...
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Article
Open AccessLongitudinal trajectories of cortical development in 22q11.2 copy number variants and typically develo** controls
Probing naturally-occurring, reciprocal genomic copy number variations (CNVs) may help us understand mechanisms that underlie deviations from typical brain development. Cross-sectional studies have identified ...
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Article
Open AccessMultiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shar...
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Article
Open AccessLocal molecular and global connectomic contributions to cross-disorder cortical abnormalities
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to arise from molecular perturbations or connectome miswiring. The unique and shared contributions of these molecular and ...
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Article
Open AccessENIGMA + COINSTAC: Improving Findability, Accessibility, Interoperability, and Re-usability
The FAIR principles, as applied to clinical and neuroimaging data, reflect the goal of making research products Findable, Accessible, Interoperable, and Reusable. The use of the Collaborative Informatics and Neur...
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Article
Open AccessAssociation between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We...
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Article
Open AccessBrain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this ...
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Article
Open AccessStructural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are simil...
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Article
Open Access1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Hu...
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Article
Open AccessBrain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group
It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated...
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Article
Open AccessAltered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study
22q11.2 deletion syndrome (22q11DS)—a neurodevelopmental condition caused by a hemizygous deletion on chromosome 22—is associated with an elevated risk of psychosis and other developmental brain disorders. Pri...
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Article
Open AccessUsing structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group
Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (M...
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Article
Open AccessLarge-scale map** of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size
The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpower...
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Article
Open AccessENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human b...
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Chapter and Conference Paper
A Deep Transfer Learning Framework for 3D Brain Imaging Based on Optimal Mass Transport
Deep learning has attracted increasing attention in brain imaging, but many neuroimaging data samples are small and fail to meet the training data requirements to optimize performance. In this study, we propos...
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Chapter
Big Data Initiatives in Psychiatry: Global Neuroimaging Studies
Big data and large-scale biobanks offer the potential to answer new types of questions as well as address older questions with greater confidence and rigor in order to overcome the ‘crisis of reproducibility’ ...
