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  1. Article

    Open Access

    Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody

    The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used...

    Thomas J. Esparza, Shiran Su, Caroline M. Francescutti… in Fluids and Barriers of the CNS (2023)

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  2. Article

    Open Access

    Sensitive detection of extremely small iron oxide nanoparticles in living mice using MP2RAGE with advanced image co-registration

    Magnetic resonance imaging (MRI) is a widely used non-invasive methodology for both preclinical and clinical studies. However, MRI lacks molecular specificity. Molecular contrast agents for MRI would be highly...

    Joong H. Kim, Stephen Dodd, Frank Q. Ye, Andrew K. Knutsen… in Scientific Reports (2021)

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  3. No Access

    Article

    Astrocytic degeneration in chronic traumatic encephalopathy

    Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repeated head traumas. Using immunohistochemistry for glial fibrillary acidic protein as a marker, plus automated quantitat...

    Eric T. Hsu, Mihika Gangolli, Shiran Su, Laurena Holleran… in Acta Neuropathologica (2018)