Carbon-Ion Radiotherapy
Principles, Practices, and Treatment Planning
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Open AccessInvolved-field radiotherapy in older patients with superficial thoracic esophageal squamous cell carcinoma: long-term outcomes and recurrence patterns
An optimal radiotherapy field for superficial esophageal carcinoma is yet to be established. We evaluated the long-term outcomes and recurrence patterns of involved-field radiotherapy (IFRT) in older patients ...
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A long-term survival case of bladder cancer with distant metastases: abscopal effect of brain metastases after stereotactic radiotherapy with immune checkpoint blockade therapy to lung metastases
Brain metastases from bladder cancer are rare, with a poor prognosis. There is no standard treatment for bladder cancer with brain metastases; thus, palliative therapy is generally provided. We report a case o...
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Open AccessRisk of secondary malignancy after radiotherapy for breast cancer: long-term follow-up of Japanese patients with breast cancer
There have been very few reports of secondary malignancies after breast cancer treatment in Asia, particularly in Japan. This study aimed to evaluate the risk of secondary malignancies after radiotherapy (RT) ...
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Ipsilateral breast tumor control following hypofractionated and conventional fractionated whole-breast irradiation for early breast cancer: a long-term follow-up
Long-term follow-up of Japanese women with breast cancer who underwent hypofractionated whole-breast irradiation (HF-WBI) has not been well documented. Therefore, we compared the treatment results of HF-WBI an...
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Abscopal complete regression of hepatocellular carcinoma with multiple pleural metastases
Hepatocellular carcinoma (HCC) with extrahepatic metastasis is rare, and its prognosis is extremely poor. There is no standard treatment for HCC with extrahepatic metastasis. We report a case of abscopal effec...
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Open AccessA clinical study of curative partial breast irradiation for stage I breast cancer using carbon ion radiotherapy
Our institute initiated carbon ion radiotherapy research for patients with stage I breast cancer in April 2013. The purpose of this article is to evaluate the treatment outcome of cases treated outside clinica...
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Open AccessMetabolic characterization of aggressive breast cancer cells exhibiting invasive phenotype: impact of non-cytotoxic doses of 2-DG on diminishing invasiveness
Metabolic reprogramming is being recognized as a fundamental hallmark of cancer, and efforts to identify drugs that can target cancer metabolism are underway. In this study, we used human breast cancer (BC) ce...
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Open AccessParathyroid carcinoma in a 13-year-old girl with a long-term survival
Parathyroid carcinoma as a cause of primary hyperparathyroidism in children is extremely rare. We report a case of parathyroid carcinoma which occurred in a 13-year-old girl who survived for more than 45 years...
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The 5-year outcomes of moderately hypofractionated radiotherapy (66 Gy in 22 fractions, 3 fractions per week) for localized prostate cancer: a retrospective study
Hypofractionated radiotherapy using fewer and larger fractional doses may be more beneficial than conventional external-beam radiotherapy for localized prostate cancer. We evaluated the 5-year outcomes of mode...
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Open AccessThe prognostic value of rectal invasion for stage IVA uterine cervical cancer treated with radiation therapy
The prognostic value of rectal invasion is still unclear in stage IVA cervical cancer. The objective of this study is to evaluate patient outcome and prognostic factors in stage IVA cervical cancer treated wit...
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Open AccessCarbon ion beam combined with cisplatin effectively disrupts triple negative breast cancer stem-like cells in vitro
Although a relatively small proportion of all breast cancer (BC), triple negative (TN) BC is responsible for a relatively large proportion of BC deaths because of its worse clinical outcome. To investigate whe...
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One shot of carbon-ion radiotherapy cured a 6-cm chemo-resistant metastatic liver tumor: a case of breast cancer
The standard treatment for metastatic liver tumor from breast cancer is systemic medical treatment, and there is controversy regarding the value of local treatment. However, there are some exceptional cases th...
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The current status of education and career paths of students after completion of medical physicist programs in Japan: a survey by the Japanese Board for Medical Physicist Qualification
To standardize educational programs and clinical training for medical physics students, the Japanese Board for Medical Physicist Qualification (JBMP) began to accredit master’s, doctorate, and residency progra...
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Comparison of hypofractionated and conventionally fractionated whole-breast irradiation for early breast cancer patients: a single-institute study of 1,098 patients
To evaluate the efficacy and safety of hypofractionated whole-breast irradiation (HF-WBI) compared with conventionally fractionated (CF) WBI.
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First experience of carbon-ion radiotherapy for early breast cancer
Breast cancer is increasingly being detected at earlier stages, and partial breast irradiation for patients with low-risk-group tumor has come to be applied in the US and Europe as an alternative to whole-bre...
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Gynecological Melanoma
Primary malignant melanoma (MM) of the gynecological organs is extremely rare. Surgical resection has been performed as the best modality for this tumor, although all patients are not necessarily suitable cand...
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Metastatic Tumors
Metastatic tumor without systemic extension, so-called oligometastasis, is a good candidate for carbon ion radiotherapy (C-ion RT). Careful patient selection must be needed before starting C-ion RT. The fracti...
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Breast Cancer
Breast cancer is a major health problem for women all over the world. In recent years, about half of the cases detected in Japan were below stage I. The standard care for early-stage breast cancer is breast-co...
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The role of chemoradiotherapy in patients with unresectable T4 breast tumors
Unresectable T4 tumors of the breast are usually treated with systemic therapies, while the role of local therapies remains debatable. This study aims to evaluate the effectiveness of chemoradiotherapy as a pa...
