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Article
Open AccessProgranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
Immune evasion is indispensable for cancer initiation and progression, although its underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known. Here, we characterize the function of t...
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Article
Open AccessCellular model system to dissect the isoform-selectivity of Akt inhibitors
The protein kinase Akt plays a pivotal role in cellular processes. However, its isoforms’ distinct functions have not been resolved to date, mainly due to the lack of suitable biochemical and cellular tools. A...
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Article
ALK positively regulates MYCN activity through repression of HBP1 expression
ALK mutations occur in 10% of primary neuroblastomas and represent a major target for precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra-high-risk phenotype resulting in ver...
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Article
Mutational dynamics between primary and relapse neuroblastomas
Alexander Schramm, Johannes Schulte and colleagues characterize 16 paired samples from patients with neuroblastoma at diagnosis and relapse using whole-exome sequencing, mRNA expression profiling, array CGH an...
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Article
Open AccessMYCN transcriptionally represses CD9 to trigger an invasion-metastasis cascade in neuroblastoma
