-
Article
Open AccessSOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry
The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases. Here, we identify SOX11 as a dependency transcripti...
-
Article
Cellular senescence in neuroblastoma
Neuroblastoma is a tumour that arises from the sympathoadrenal lineage occurring predominantly in children younger than five years. About half of the patients are diagnosed with high-risk tumours and undergo i...
-
Article
Open AccessMYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells
MYCN is an oncogenic driver in neural crest-derived neuroblastoma and medulloblastoma. To better understand the early effects of MYCN activation in a neural-crest lineage context, we profiled the transcriptome of...
-
Article
Open AccessAuthor Correction: Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
-
Article
Open AccessPublisher Correction: In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
-
Article
Open AccessIntegrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes
Long intergenic non-coding RNAs (lincRNAs) are emerging as integral components of signaling pathways in various cancer types. In neuroblastoma, only a handful of lincRNAs are known as upstream regulators or do...
-
Article
ALK positively regulates MYCN activity through repression of HBP1 expression
ALK mutations occur in 10% of primary neuroblastomas and represent a major target for precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra-high-risk phenotype resulting in ver...
-
Article
Open AccessIn silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors
Chemotherapy resistance is responsible for high mortality rates in neuroblastoma. MYCN, an oncogenic driver in neuroblastoma, controls pluripotency genes including LIN28B. We hypothesized that enhanced embryonic ...
-
Article
Open AccessTBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive transcription factors on 17q marked by H3K27ac defin...
-
Article
Open AccessExpressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice
Reverse transcription quantitative PCR (RT-qPCR) is the gold standard method for gene expression analysis on mRNA level. To remove experimental variation, expression levels of the gene of interest are typicall...
