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Article
Open AccessNeoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial
Antibodies targeting the immune checkpoint molecules PD-1, PD-L1 and CTLA-4, administered alone or in combination with chemotherapy, are the standard of care in most patients with metastatic non-small-cell lun...
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Article
Open AccessIdentification of lumped stiffness parameters for a motorcycle model in investigating weave and wobble
In motorcycle dynamics, great importance is attributed to the study of the weave and wobble vibration modes and, in particular, to the effects of the flexibility of structural components on their stability. Th...
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Article
Open AccessGrößenprogrediente, unklare Raumforderung der Stirn nach vorherigem Trauma
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Article
Open AccessBRAF inhibitors in BRAF V600E-mutated ameloblastoma: systematic review of rare cases in the literature
Ameloblastoma in 66% of the cases harbor a somatic mutation of the “mitogen-activated protein kinase” signaling pathway (BRAF V600E). In V600E mutations, BRAF is in the permanent “on” state and relays the grow...
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Protocol
Nanopore Sequencing Techniques: A Comparison of the MinKNOW and the Alignator Sequencers
Whole genome and transcriptome analyses represent powerful tools. Despite improvements in sequencing methodology, whole transcriptome analyses are still tedious, especially for methodologies producing long rea...
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Article
Open AccessSyntaxin 18 regulates the DNA damage response and epithelial-to-mesenchymal transition to promote radiation resistance of lung cancer
Radiotherapy is an important modality in lung cancer treatment. Despite advances in treatment planning and dose delivery, patient benefit is still limited by in-field relapse and metastatic recurrence. Simulta...
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Article
Open AccessEIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma
Neuroblastoma (NB) accounts for 15% of cancer-related deaths in childhood despite considerable therapeutic improvements. While several risk factors, including MYCN amplification and alterations in RAS and p53 pat...
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Article
Open AccessThe long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma
Glioblastoma is the most common malignant primary brain tumor. To date, clinically relevant biomarkers are restricted to isocitrate dehydrogenase (IDH) gene 1 or 2 mutations and O6-methylguanine DNA methyltran...
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Chapter
Computer-Assisted Surgery and Intraoperative Navigation in Acute Maxillofacial Trauma Repair
In computer-assisted maxillofacial trauma repair, the algorithm >diagnosis → planning and simulation → surgical procedure → validation and quality control< has been established.
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Article
Open AccessFunctional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis
Lung cancer mortality largely results from metastasis. Despite curative surgery many patients with early-stage non-small cell lung cancer ultimately succumb to metastatic relapse. Current risk reduction strate...
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Article
Open AccessLong-term follow-up of full-arch immediate implant-supported restorations in edentulous jaws: a clinical study
This study aims to show the long-time stability of straight and tilted implants loaded immediately with a provisional resin bridge followed by a definitive prosthodontic rehabilitation in edentulous jaws despi...
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Article
Open AccessRuntime verification of real-time event streams under non-synchronized arrival
We study the problem of online runtime verification of real-time event streams. Our monitors can observe concurrent systems with a shared clock, but where each component reports observations as signals that ar...
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Article
Open AccessN-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma
N-Myc is a transcription factor that is aberrantly expressed in many tumor types and is often correlated with poor patient prognosis. Recently, several lines of evidence pointed to the fact that oncogenic acti...
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Article
Maxillofacial injuries in severely injured patients after road traffic accidents—a retrospective evaluation of the TraumaRegister DGU® 1993–2014
It was the aim of the study to analyse the prevalence of maxillofacial trauma (MFT) in severely injured patients after road traffic accidence (RTA) and to investigate associated factors.
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Article
Cancer evolution, mutations, and clonal selection in relapse neuroblastoma
The notion of cancer as a complex evolutionary system has been validated by in-depth molecular analyses of tumor progression over the last years. While a complex interplay of cell-autonomous programs and cell-...
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Article
Open AccessAutogenous bone grafts in oral implantology—is it still a “gold standard”? A consecutive review of 279 patients with 456 clinical procedures
This study assessed the clinical outcomes of graft success rate and early implant survival rate after preprosthetic alveolar ridge reconstruction with autologous bone grafts.
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Article
Multicenter study on the use of patient-specific CAD/CAM reconstruction plates for mandibular reconstruction
For the new generation of mandibular reconstruction, patient-specific mandible reconstruction plates (PSMPs) have been developed which are milled from titanium after preoperative computer planning using CAD/C...
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Article
Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice
The MYCN oncogene is a strong genetic marker associated with poor prognosis in neuroblastoma (NB). Therefore, MYCN gene amplification and subsequent overexpression provide a possible target for new treatment appr...
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Article
Telomerase activation by genomic rearrangements in high-risk neuroblastoma
Activation of telomere maintenance mechanisms—caused by novel somatic rearrangements of TERT, by MYCN amplification, or ATRX mutations—is a hallmark of high-risk neuroblastomas.
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Article
Mutational dynamics between primary and relapse neuroblastomas
Alexander Schramm, Johannes Schulte and colleagues characterize 16 paired samples from patients with neuroblastoma at diagnosis and relapse using whole-exome sequencing, mRNA expression profiling, array CGH an...
