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Article
Passive smoking and nasopharyngeal colonization by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in daycare children
Exposure to tobacco smoke may be associated with higher risk of nasopharyngeal colonization and infection by Streptococcus pneumoniae (SP), Haemophilus influenzae (HI), and Moraxella catarrhalis (MC). This study ...
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Article
Absence of Helicobacter pylori infection in coronary atherosclerosis disease in Northeast of Iran
Atherosclerosis is an inflammatory disorder in which infectious agents are incriminated as contributors. It is suggested that Helicobacter pylori may be a risk factor of atherosclerosis.
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Article
Sequence Analysis of lip R: A Good Method for Molecular Epidemiology of Clinical Isolates of Mycobacterium tuberculosis
Advances in DNA sequencing have greatly enhanced the molecular epidemiology studies. In order to assess evolutionary and phylogenetic relation of Mycobacterium tuberculosis isolates several gene targets were eva...
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Article
APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice
Numerous studies have demonstrated that targeting immunogens to FcγR on antigen-presenting cells (APCs) can selectively uptake and increase cellular immunity in vitro and in vivo. Therefore, the present study was...
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Article
Which quantitative method in determination of the thyroid hormone levels is more consistent with the clinical symptoms of the thyroid disorders?
Various methods have been used to determine thyroid-stimulating hormone (TSH) and thyroid hormone concentrations in medical diagnostic laboratories. Selection of a suitable method for diagnosis and monitoring ...
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Article
Evaluation of nasopharyngeal microbial flora and antibiogram and its relation to otitis media with effusion
Acute otitis media and otitis media with effusion (OME) are the main causes of hearing impairment in children which require proper treatment, mainly antibiotic therapy. Patients whom were appropriate candidate...
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Article
TB trifusion antigen adsorbed on calcium phosphate nanoparticles stimulates strong cellular immunity in mice
Among various vaccine candidates, subunit vaccines play an important role in immune protection against tuberculosis (TB). Calcium phosphate (CP) is considered as a strong inorganic adjuvant due to its great po...
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Article
Construction and immunogenicity of a new Fc-based subunit vaccine candidate against Mycobacterium tuberculosis
As an ancient disease, tuberculosis (TB) is a major global health threat. Therefore, there is an urgent need for an effective and safe anti-TB vaccine. In the current study, a delivery system of Fc domain of m...
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Article
Open AccessMolecular characterization and genetic relatedness of clinically Acinetobacter baumanii isolates conferring increased resistance to the first and second generations of tetracyclines in Iran
The increasing resistance of Acinetobacter baumannii to antibiotics has recently been regarded as a notable therapeutic difficulty. Evaluating resistance rates of some A. baumannii isolates to tetracyclines had a...
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Article
Selection of DNA aptamers against Mycobacterium tuberculosis Ag85A, and its application in a graphene oxide-based fluorometric assay
The Mycobacterium Ag85 complex is the major secretory protein of M. tuberculosis. It is a potential marker for early diagnosis of tuberculosis (TB). The authors have identified specific aptamers for Ag85A (FbpA) ...
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Article
Prevalence of Listeria monocytogenes in cerebrospinal fluid obtained from hospitalized patients
The aim of the present study was to determine the occurrence of Listeria monocytogenes in cerebrospinal fluid (CSF) samples obtained from patients with meningitis symptoms. A total of 102 CSF samples which were r...
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Article
Open AccessModified genome comparison method: a new approach for identification of specific targets in molecular diagnostic tests using Mycobacterium tuberculosis complex as an example
The first step of designing any genome-based molecular diagnostic test is to find a specific target sequence. The modified genome comparison method is one of the easiest and most comprehensive ways to achieve ...
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Article
Open AccessEpinecidin-1, a highly potent marine antimicrobial peptide with anticancer and immunomodulatory activities
Antibiotic-resistant pathogens are an emerging threat in this century. Epinecidin-1 is a multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides) has been shown to ha...
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Article
Open AccessComment on “nontuberculous mycobacterial infection after lung transplantation: a report of four cases”
Nontuberculous mycobacteria can lead to pulmonary infection in lung transplantation cases, which is associated with high mortality rates. We hereby thank Dr. Ose et al. very much for their report on “Nontuberc...
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Article
Open AccessGenotypic and phenotypic characterization of Mycobacterium tuberculosis resistance against fluoroquinolones in the northeast of Iran
Fluoroquinolones are broad-spectrum antibiotics that are recommended, and increasingly important, for the treatment of multidrug-resistant tuberculosis (MDR-TB). Resistance to fluoroquinolones is caused by mut...
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Article
Open AccessEpidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)
Although many species of mycoplasmas regard as normal flora, but some species causes serious genital disease. In Iran several epidemiological studies have documented the prevalence of Mycoplasma hominis, M. genit...
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Article
Targeting novel genes for simultaneous detection of five fungal and bacterial agents from BAL samples using multiplex PCR assay
The main purpose of our study was to evaluate multiplex PCR assay targeting novel genes for detection of five fungal and bacterial agents in BAL samples; because many fungi and bacteria that cause respiratory ...
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Article
Peptides with Dual Antimicrobial-Anticancer Activity Derived from the N-terminal Region of H. pylori Ribosomal Protein L1 (RpL1)
Whereas the traditional approaches of cancer therapy including radiotherapy, chemotherapy, and immunotherapy have failed to properly treat cancer due to the condition of the space inside the tumor with the hyp...
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Article
Open AccessIn vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria
Melittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy. However, there is evidence showing melittin has non-promising effects suc...
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Article
Inconsistency of QuantiFERON-TB Gold Test and Tuberculin Skin Test Results in the Evaluation of Latent Tuberculosis Infection in Health Care Workers
Problem considered: Working in hospital wards, especially the infectious and pulmonary diseases wards, increases the likelihood of the risk of the health care staff with a variety of infectious factors, including...
