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  1. No Access

    Article

    Production and Evaluation of Ag85B:HspX:hFcγ1 Immunogenicity as an Fc Fusion Recombinant Multi-Stage Vaccine Candidate Against Mycobacterium tuberculosis

    An urgent need is to introduce an effective vaccine against Mycobacterium tuberculosis (M.tb) infection. In the present study, a multi-stage M.tb immunodominant Fcγ1 fusion protein (Ag85B:HspX:hFcγ1) was designed...

    Mohsen Karbalaei, Arman Mosavat, Saman Soleimanpour, Hadi Farsiani… in Current Microbiology (2024)

  2. No Access

    Article

    Gene Expression Study of Host and Mycobacterium tuberculosis Interactions in the Manifestation of Acute Tuberculosis

    Mycobacterium tuberculosis (M.tb) could induce type IV hypersensitivity. The chemotaxis of the leukocytes toward the site of infection and producing matrix metalloproteinases (MMPs) are key factors in the immune ...

    Shadi Abbasnia, Sara Hajimiri, Mozhdeh Jafari Rad… in Applied Biochemistry and Biotechnology (2023)

  3. No Access

    Article

    Evaluation of Mutations Related to Streptomycin Resistance in Mycobacterium tuberculosis Clinical Isolates

    Drug resistance to streptomycin in the clinical isolates of Mycobacterium tuberculosis (MTB) needs special consideration. It can mostly be caused by mutations in four genes with the names rpsL, rrs, gidB, and whi...

    Maryam Shafipour, Hesamaddin Shirzad-Aski, Abdolmajid Mohammadzadeh… in Current Microbiology (2022)

  4. No Access

    Article

    Antimicrobial Peptides as a Promising Therapeutic Strategy for Neisseria Infections

    Antibiotic resistance is already widespread in the world, and it has become a great health problem. Therefore, comprehensive efforts are needed to minimize the resistance. The exploration of alternative therap...

    Parvin Askari, Masoud Yousefi, Mohsen Foadoddini, Alireza Neshani… in Current Microbiology (2022)

  5. No Access

    Article

    Mycobacterium tuberculosis ty** using Allele-specific oligonucleotide multiplex PCR (ASO–PCR) method

    Mycobacterium tuberculosis (M. tuberculosis) genoty** provides valuable information related to the origin and the evolution of the isolates. This study aimed to evaluate the applicability of single-nucleotide p...

    Maryam Shafipour, Hesamaddin Shirzad-Aski, Ezzat Allah Ghaemi… in Current Microbiology (2021)

  6. No Access

    Article

    TB trifusion antigen adsorbed on calcium phosphate nanoparticles stimulates strong cellular immunity in mice

    Among various vaccine candidates, subunit vaccines play an important role in immune protection against tuberculosis (TB). Calcium phosphate (CP) is considered as a strong inorganic adjuvant due to its great po...

    Yousef Amini, Bagher Moradi, Mohsen Tafaghodi… in Biotechnology and Bioprocess Engineering (2016)

  7. No Access

    Article

    APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice

    Numerous studies have demonstrated that targeting immunogens to FcγR on antigen-presenting cells (APCs) can selectively uptake and increase cellular immunity in vitro and in vivo. Therefore, the present study was...

    Saman Soleimanpour, Hadi Farsiani, Arman Mosavat… in Applied Microbiology and Biotechnology (2015)

  8. No Access

    Article

    Sequence Analysis of lip R: A Good Method for Molecular Epidemiology of Clinical Isolates of Mycobacterium tuberculosis

    Advances in DNA sequencing have greatly enhanced the molecular epidemiology studies. In order to assess evolutionary and phylogenetic relation of Mycobacterium tuberculosis isolates several gene targets were eva...

    Samaneh Saedi, Masoud Youssefi, Hadi Safdari, Saman Soleimanpour… in Current Microbiology (2015)