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Reference Work Entry In depth
Glyco-engineered Therapeutic Antibodies as a Second-Generation Antibody Therapy
Since the establishment of monoclonal antibody production using mouse hybridoma technology in the 1980s, there has been expanding progress and continuous technological improvement in the development of therape...
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Living Reference Work Entry In depth
Glyco-engineered Therapeutic Antibodies as a Second-Generation Antibody Therapy
Since the establishment of monoclonal antibody production using mouse hybridoma technology in the 1980s, there has been expanding progress and continuous technological improvement in the development of therape...
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Article
Open AccessTwo mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood
Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies. Ther...
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Chapter and Conference Paper
Non-fucosylated Therapeutic Antibodies: The Next Generation of Therapeutic Antibodies
Therapeutic antibody IgG1 has two N-linked oligosaccharide chains bound to the Fc region. The oligosaccharides are of the complex biantennary type, composed of a trimannosyl core structure with the presence or ab...
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Article
Non-fucosylated therapeutic antibodies: the next generation of therapeutic antibodies
Therapeutic antibody IgG1 has two N-linked oligosaccharide chains bound to the Fc region. The oligosaccharides are of the complex biantennary type, composed of a trimannosyl core structure with the presence or...
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Article
Open AccessDouble knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC
Antibody-dependent cellular cytotoxicity (ADCC) is greatly enhanced by the absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the clinical efficacy of anticancer activ...
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Chapter and Conference Paper
Thermodynamic and kinetic effects of human IgG1 defucosylation on IgG1-FcγRIIIa interaction
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Chapter and Conference Paper
Generation of an industrially ideal host cell line for producing completely-defucosylated antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC)
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Article
Construction of humanized anti-ganglioside monoclonal antibodies with potent immune effector functions
Gangliosides GD3, GD2 and GM2, which are the major gangliosides expressed on most human cancers of neuroectodermal and epithelial origin, have been focused on as effective targets for passive immunotherapy wi...
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Article
Recombinant antibodies against ganglioside expressed on tumor cells
Several gangliosides such as GM2, GD2, and GD3 have been thought of as target molecules for active or passive immunotherapy of human cancers because of their dominant expression on the tumor cell surface, esp...
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Article
Therapeutic potential of chimeric anti-(ganglioside GD3) antibody KM871: antitumor activity in xenograft model of melanoma and effector function analysis
KM871 is a chimeric antibody recognizing ganglioside GD3, which is one of the major gangliosides expressed on the cell surface of human tumors of neuroectodermal origin. This study demonstrates the antitumor ...
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Article
Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells
Vascular endothelial growth factor (VEGF) is a principal regulator of vasculogenesis and angiogenesis. VEGF expresses its effects by binding to two VEGF receptors, Flt-1 and KDR. However, properties of Flt-1 a...
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Article
Panosialins, inhibitors of an α1,3-fucosyltransferase Fuc-TVII, suppress the expression of selectin ligands on U937 cells
Panosialins A and B were isolated as inhibitors of an α1,3-fucosyltransferase, Fuc-TVII, which is a key enzyme in the biosynthesis of selectin ligands, from culture broth of Streptomyces sp. Panosialins A and ...
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Article
A mouse/human chimeric anti-(ganglioside GD3) antibody with enhanced antitumor activities
Ganglioside GD3, which is one of the major gangliosides expressed on the cell surface of human tumors of neuroectodermal origin has been focused on as a target molecule for passive immunotherapy. We have clone...
