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  1. No Access

    Article

    Therapeutic potential of chimeric anti-(ganglioside GD3) antibody KM871: antitumor activity in xenograft model of melanoma and effector function analysis

    KM871 is a chimeric antibody recognizing ganglioside GD3, which is one of the major gangliosides expressed on the cell surface of human tumors of neuroectodermal origin. This study demonstrates the antitumor ...

    Junji Kanazawa, So Ohta, Kenya Shitara, Fumiko Fujita… in Cancer Immunology, Immunotherapy (2000)

  2. No Access

    Article

    Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration

    2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine (Cl-F-araA) is a novel deoxyadenosine analog, which inhibits DNA synthesis by inhibiting DNA polymerase α and ribonucleotide reductase. Cl-F-araA sho...

    Takeshi Takahashi, Junji Kanazawa, Shiro Akinaga… in Cancer Chemotherapy and Pharmacology (1999)

  3. No Access

    Article

    Metabolism and ribonucleotide reductase inhibition of (E  )-2′-deoxy-2′-(fluoromethylene)cytidine, MDL 101,731, in human cervical carcinoma HeLa S3 cells

    (E )-2′-Deoxy-2′-(fluoromethylene)cytidine, MDL 101,731, has shown potent antitumor activity against various human xenograft models. Purpose: The purpose of this study was to elucidate the mechanism of the antit...

    Takeshi Takahashi, Akiko Nakashima, Junji Kanazawa… in Cancer Chemotherapy and Pharmacology (1998)