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Article
Role of the cGAS–STING pathway in systemic and organ-specific diseases
Cells are equipped with numerous sensors that recognize nucleic acids, which probably evolved for defence against viruses. Once triggered, these sensors stimulate the production of type I interferons and other...
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Article
The (Orf)ull truth about IRF5 and type I interferons in SLE
Exactly how nucleic acids trigger type I interferon responses via certain Toll-like receptors has been uncertain. Now, a new pathway involving gene products previously linked to systemic lupus erythematosus bu...
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Article
Open AccessThe early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent
Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light (UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease. The pathogenic link between ski...
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Article
Aspirin meets cGAS
Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (...
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Article
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
Lupus-like disease is driven by NETs enriched in mitochondrial DNA.
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Article
Open AccessInnate and adaptive immune responses to dead and dying cells
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Chapter
Naturally Occurring Autoantibodies to Apoptotic Cells
Subsets of IgM naturally occurring autoantibodies (NAbs) bind to the cell surface membranes of dying cells. The antibodies predominantly have specificities against lipid antigens or oxidized lipids. Chief amon...
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Article
Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature
Yanick Crow and colleagues show that mutations in ACP5, which encodes tartrate-resistant acid phosphatase, cause spondyloenchondrodysplasia, a bone dysplasia with autoimmunity. The affected individuals had elevat...
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Article
Cytokines as therapeutic targets in SLE
A number of cytokine pathways are important in the disease process of SLE, and several biological agents for SLE have been developed that target different cytokines or their receptors. This Review discusses th...
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Article
Open AccessB-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin
B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family that regulate B-cell maturation, survival, and function. They are overexpressed ...
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Article
Autoimmunity: apoptotic fats grease transcription
Transcription factors known for handling the body's response to lipids promote clearance of apoptotic cells by macrophages, according to new research (pages 1266–1272
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Article
IL-1α responds to necrotic cell death
Necrosis induces inflammation, but how necrotic cells signal to immune cells was poorly understood. New work by Chen et al. shows that IL-1α acts as a mediator, translating a signal from the necrotic cells to ind...
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Article
Shining light on lupus and UV
People exposed to sunlight can develop erythema, DNA damage, and photoimmunosupression. Extended exposure of normal epidermis to sunlight will induce dysmorphic keratinocytes with pyknotic nuclei scattered thr...
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Article
Apoptosis in the effector phase of autoimmune diabetes, multiple sclerosis and thyroiditis
The immune system is unusual in two respects. It produces billions of new cells daily that traffic throughout the body and cells within the system proliferate rapidly following exposure to an infectious agent....
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Chapter
Ribosomal RNP
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Chapter
Antiribosomal Antibodies in SLE, Infection, and Following Deliberate Immunization
It has long been known that patients with systemic lupus erythematosus (SLE) and related diseases have, in addition to antinuclear antibodies (ANA), autoantibodies directed against cytoplasmic constituents1,2. In...
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Article
Use of synthetic peptides for the detection and quantification of autoantibodies
The rapid progress made over the last 10 years in the identification of individual autoantigens and in the localization of the epitopes involved, has resulted in a parallel reduction in the complexity of the a...
