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Article
Open AccessThe engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity
Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In so...
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Article
Open AccessAcazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models
Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterized by generalized fibrosis affecting particularly the lungs and...
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Article
Open AccessB-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin
B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family that regulate B-cell maturation, survival, and function. They are overexpressed ...
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Article
An APRIL to remember: novel TNF ligands as therapeutic targets
TNF family members have a multitude of crucial roles in the immune response, and numerous companies have invested millions of dollars to develop therapeutic dr...
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Article
Erratum: Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
Nature Immunology 5, 752–760 (2004). The published version of this article failed to include the microarray accession numbers. They are listed here: Geo microarray accession numbers. GSE1304, Control and Il31 ...
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Article
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
T cell–derived cytokines are important in the development of an effective immune response, but when dysregulated they can promote disease. Here we identify a four-helix bundle cytokine we have called interleuk...
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Article
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I cytokine receptor that is selectively expressed in ...
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Article
TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
B cells are important in the development of autoimmune disorders by mechanisms involving disregulated polyclonal B-cell activation, production of pathogenic antibodies, and co-stimulation of autoreactive T cel...
