-
Article
The gut microbiome in systemic lupus erythematosus: lessons from rheumatic fever
For more than a century, certain bacterial infections that can breach the skin and mucosal barriers have been implicated as common triggers of autoimmune syndromes, especially post-infection autoimmune disease...
-
Article
Blood clots and TAM receptor signalling in COVID-19 pathogenesis
We suggest that the exuberant blood clotting and immune hyper-reaction seen in patients with COVID-19 may be exacerbated by depletion of the same regulator. This agent is protein S, which is both an anticoagul...
-
Article
Open AccessTissue resident and follicular Treg cell differentiation is regulated by CRAC channels
T regulatory (Treg) cells maintain immunological tolerance and organ homeostasis. Activated Treg cells differentiate into effector Treg subsets that acquire tissue-specific functions. Ca2+ influx via Ca2+ release...
-
Article
The microbiome in SLE pathogenesis
Systemic lupus erythematosus (SLE), the embodiment of a multi-organ autoimmune disease, results from hyperactivation of host-defence pathways and immune recognition of the most fundamental building blocks of l...
-
Article
Open AccessHierarchy of human IgG recognition within the Staphylococcus aureus immunome
Staphylococcus aureus is an opportunistic pathogen that causes a range of serious infections associated with significant morbidity, by strains increasingly resistant to antibiotics. However, to date all candidate...
-
Article
Open AccessAutoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis
Immunoglobulin M (IgM) autoreactivity to malondialdehyde (MDA) protein modifications is part of the natural antibody repertoire in health and may have beneficial functions. In contrast, IgG anti-MDA are increa...
-
Protocol
Unbiased RACE-Based Massive Parallel Surveys of Human IgA Antibody Repertoires
For investigations of human B-cell receptor (BCR) repertoires, we have developed a protocol for large-scale surveys of human antibody heavy chain (VH) rearrangements. Here we study IgA repertoires, as more IgA...
-
Article
Erratum to: Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis
-
Article
Open AccessProtective natural autoantibodies and lupus pathogenesis
-
Article
Natural IgM: Beneficial Autoantibodies for the Control of Inflammatory and Autoimmune Disease
Natural IgM are highly represented in the circulation at birth, and these often autoreactive antibodies have been postulated to have innate-like properties and play crucial roles in apoptotic cell clearance, t...
-
Article
Protective autoantibodies in the rheumatic diseases: lessons for therapy
Pathogenic IgG autoantibodies have established roles in diseases including systemic lupus erythematosus and rheumatoid arthritis. Less familiar are the influences of naturally arising IgM autoantibodies, which...
-
Chapter
Naturally Occurring Autoantibodies to Apoptotic Cells
Subsets of IgM naturally occurring autoantibodies (NAbs) bind to the cell surface membranes of dying cells. The antibodies predominantly have specificities against lipid antigens or oxidized lipids. Chief amon...
-
Article
Rethinking the red wolf disease: does Protein S suppress systemic lupus erythematosus clinical activity?
In systemic lupus erythematosus, the forces responsible for disease initiation and self-perpetuation in these clinically heterogeneous populations remain poorly understood. Recent studies of the TAM (Tyro3, Ax...
-
Article
Open AccessChronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Oxidation
Chronic lymphocytic leukemia (CLL) represents the outgrowth of a CD5+ B cell. Its etiology is unknown. The structure of membrane Ig on CLL cells of unrelated patients can be remarkably similar. Therefore, antigen...
-
Article
Confounding B-cell defences: lessons from a staphylococcal superantigen
Superantigens are microbial toxins that target large sets of lymphocytes through conserved variable-region sites on antigen receptors. Studies of superantigens...
-
Article
Natural antibodies and innate-like B cells
-
Article
Natural antibodies and the autoimmunity of atherosclerosis
In recent years, the subject of natural antibodies has been revisited and the immunobiological roles of these humoral factors are being better defined. These antibodies are secreted by distinct sets of innate-...
-
Article
B cell superantigens: a microbe’s answer to innate-like B cells and natural antibodies
Marginal zone B cells and B-1 cells have been termed innate-like B cells as they express limited repertoires that play special roles in immune defenses against common infections. These B cells are the sources ...
-
Article
Roles of B cells in rheumatoid arthritis
B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. They are the source of the rheumatoid factors and anticitrullinated protein antibodies, which contribute to immune complex...
-
Article
Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL
During the progression of atherosclerosis, autoantibodies are induced to epitopes of oxidized low-density lipoprotein (oxLDL) and active immunization of hypercholesterolemic mice with oxLDL ameliorates atherog...
