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Article
Role of the cGAS–STING pathway in systemic and organ-specific diseases
Cells are equipped with numerous sensors that recognize nucleic acids, which probably evolved for defence against viruses. Once triggered, these sensors stimulate the production of type I interferons and other...
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Article
Open AccessThe early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent
Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light (UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease. The pathogenic link between ski...