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Article
Open AccessThe JAK1/2 inhibitor ruxolitinib in patients with COVID-19 triggered hyperinflammation: the RuxCoFlam trial
Dysregulated hyperinflammatory response is key in the pathogenesis in patients with severe COVID-19 leading to acute respiratory distress syndrome and multiorgan failure. Whilst immunosuppression has been prov...
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Article
Die Pandemie bewältigen – Verlegungskonzept von COVID-19-Intensivpatienten und Non-COVID-19-Intensivpatienten in Baden-Württemberg
Stark ansteigende COVID-19-Erkrankungen drohten im Herbst 2020 zu einer bedrohlichen lokalen Überlastung von Intensivstationen zu führen. Um dies zu verhindern, wurde in Baden-Württemberg ein landesweites Verl...
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Article
International registry on the use of the CytoSorb® adsorber in ICU patients
The aim of this clinical registry is to record the use of CytoSorb® adsorber device in critically ill patients under real-life conditions.
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Article
Elimination rates of electrolytes, vitamins and trace elements during continuous renal replacement therapy with citrate CVVHD: influence of treatment dose
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Article
Group A streptococcal vertebral osteomyelitis presenting with acute quadriplegia
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Article
Kindliches Schädel-Hirn-Trauma
Die Studie untersucht den Stellenwert von Dekompressionsoperationen nach kindlichem Schädel-Hirn-Trauma (SHT), die sekundär im Verlauf der Intensivtherapie durchgeführt wurden.
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Article
Letaler Verlauf nach Mehrfachverletzung
Bei Mehrfachverletzungen mit tödlichem Ausgang ist das Thoraxtrauma unverändert in 25% der Fälle die Todesursache. Anhand eines Falles mit letalem Ausgang wird die Problematik dargestellt und unter Berücksicht...
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Article
Ischämie- und Reperfusion des intestinalen und hepatischen Stromgebiets bei thorakalen Crossclam**
Hohes Aortenclam** geht im proximalen Stromgebiet mit ausgeprägter Hypertension und deren potenziellen Komplikationen einher. Darüber hinaus sind die betroffenen Patienten durch die perioperativ unumgänglich...
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Chapter
Metabolic Effects of Adrenergic Drugs
Vasoactive drugs are widely used in intensive care medicine to restore hemodynamic stability. Therapy can be led by blood pressure and cardiac output, but it can also be extended to regional hemodynamic and in...
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Chapter and Conference Paper
Metabolic Effects of Adrenergic Drugs
Vasoactive drugs are widely used in intensive care medicine to restore hemodynamic stability. Therapy can be led by blood pressure and cardiac output, but it can also be extended to regional hemodynamic and in...
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Article
Increased ileal-mucosal-arterial PCO2 gap is associated with impaired villus microcirculation in endotoxic pigs
Objective: To investigate whether an increased ileal-mucosal-arterial PCO2 gap (ΔPCO2) during hyperdynamic porcine endotoxemia is associated with impaired villus microcirculation. Design: Prospe...
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Article
Effects of nicotinamide, an inhibitor of PARS activity, on gut and liver O2 exchange and energy metabolism during hyperdynamic porcine endotoxemia
Objective: To investigate the effects of nicotinamide (NIC), an inhibitor of poly(ADP-ribose) synthetase (PARS), on intestinal and liver perfusion, O2 kinetics, and energy metabolism over 24 h o...
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Article
Pulsed laser spectroscopy in muonium and deuterium
The 1s–2s energy interval in the muonium (μ+e−) atom has been measured by Doppler free two photon laser spectroscopy. A value of 2455528941.0(9.8) MHz has been obtained in good agreement with quantum electrodynam...
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Article
Production of pulsed ultraslow muons and first μSR experiments on thin metallic and magnetic films
Standard muon spin rotation (μSR) spectroscopy implants 4 MeV spin-polarized positive muons to investigate the bulk properties of matter. Success in producing epithermal muons opens interesting possibilities f...
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Article
Therapeutische Beeinflussung des Hepato-Splanchnikusgebiets bei Trauma und Sepsis Mehr als VO2/DO2 Verhältnisse?
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Article
Ileal microcirculation and mucosal acidosis during hyperdynamic porcine endotoxemia
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Chapter and Conference Paper
Einfluß von Iloprost auf die intestinale Perfusion and Energiebilanz im hyperdynamen septischen Schock beim Schwein
Das zunehmende Ungleichgewicht zwischen Sauerstoffangebot und -verbrauch im Splanchnicusgebiet stellt ein charakteristisches Merkmal des prolongierten septischen Schockes dar. In einem Kurzzeitmodell des endot...
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Chapter and Conference Paper
Norepinephrine Versus L-NMMA in Hyperdynamic Septic Shock
Septic shock is characterized by increased cardiac output and arterial hypotension despite adequate fluid resuscitation (ACCP/SCCM Consensus Conference 1922). There is experimental evidence that endotoxin-indu...
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Article
Monitoring the hepato-splanchnic region in the critically ill patient
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Article
Endogenous glucose release in hyperdynamic porcine endotoxin shock: NG-monomethyl-L-arginine (L-NMMA) versus noradrenaline