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Article
Open AccessTriangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance
Ketone bodies (KBs) are an alternative energy supply for brain functions when glucose is limited. The most abundant ketone metabolite, 3-β-hydroxybutyrate (BOHBUT), has been suggested to prevent or delay cogni...
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Article
Open AccessValidation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics
Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter the target’s expression or function, as a tool to anticipate the effect of drug a...
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Article
Obesity and the paradox of mortality and heart failure hospitalization in heart failure with preserved ejection fraction
Limited data exist on the association of obesity with both hospitalization and mortality in patients with heart failure with preserved ejection fraction (HFpEF), especially in the real-world ambulatory setting...
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Article
Open AccessSupport, technology and mental health: correlates of trainee workplace satisfaction
Low physician workplace satisfaction may negatively impact patient care. Dissatisfaction may begin during residency training, where trainees face lower autonomy and less control over work conditions. The theor...
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Chapter
Infective Endocarditis
Endocarditis is the inflammation of the cardiac endocardium and may affect the cardiac valves, mural endocardium, or surface of catheters or devices implanted in the heart. The inflammation may be secondary to...
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Article
Role of Coronary Calcium Score to Identify Candidates for ASCVD Prevention
In this review, we describe the mechanism behind coronary artery calcification formation and detection, as well as its implication in cardiovascular disease (CVD) risk stratification, intervention, and prognos...
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Article
Open AccessGWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of...
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Article
Ularitide in Acute Heart Failure
This review article will summarize the currently available data for ularitide in acute decompensated heart failure (ADHF).
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Article
Premature Coronary Heart Disease in South Asians: Burden and Determinants
While the burden of cardiovascular disease (CVD) is on the decline globally, it is on the rise among South Asians. South Asians are also believed to present early with coronary artery disease (CAD) compared wi...
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Article
Open AccessMendelian Randomisation study of the influence of eGFR on coronary heart disease
Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear...
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Article
An Update on Gender Disparities in Coronary Heart Disease Care
Coronary heart disease (CHD), traditionally considered a male disease, causes far more deaths in women than cancer. The prevalence of CHD is lower in women at any age, but with advancing age, this differential...
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Article
Complex disease genetics: present and future translational applications
A report on the British Atherosclerosis Society autumn meeting 'Genetics of Complex Diseases', Cambridge, UK, 17-18 September 2009.
