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Article
Systematic analysis and validation of differential gene expression in ovarian serous adenocarcinomas and normal ovary
Cancer of the ovary confers the worst prognosis among women with gynecological malignancies, primarily because most ovarian cancers are diagnosed at late stage. Hence, there is a substantial need to develop ne...
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Article
Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth
Intravenously-applied bacteria tend to accumulate in tumors and can sporadically lead to tumor regression. Systemic administration of attenuated Salmonella typhimurium is safe and has shown no significant adverse...
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Article
Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate
To characterize the stability, pharmacokinetics and metabolism of analogs of gossypol, apogossypol and apogossypol hexaacetate to provide a basis for comparison.
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Protocol
Yeast and Mammalian Two-Hybrid Systems for Studying Protein-Protein Interactions
An important step in the analysis of protein function is identification of the interaction partners of each protein. The two-hybrid system has been widely used to identify and explore protein-protein interacti...
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Article
Bcl-2 Gene Family and Related Proteins in Mammary Gland Involution and Breast Cancer
The Bcl-2 gene family regulates tissuedevelopment and tissue homeostasis through the interplayof survival and death factors. Family members arecharacterized as either pro-apoptotic or anti-apoptotic, depending...
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Article
Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics
Malignant glioma cells are susceptible to CD95(Fas/APO-1)-mediated apoptosis triggered by agonistic antibody. Here we examined the proapoptotic effects of the natural CD95 ligand, a cytotoxic cytokine homolog...
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Article
Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis
Cytokine-mediated cell death in tumor cells can be achieved through endogenous nitric oxide (NO) from within tumor cells or exogenous NO from either activated macrophages or endothelial cells. The purpose of ...
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Chapter
Bcl-2 family proteins and the regulation of programmed cell death in leukemia and lymphoma
Members of the bcl-2 gene family play a central role in regulating the relative sensitivity and resistance of cells to a wide variety of apoptotic stimuli. The first member of this multigene family ,bcl-2, was di...
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Chapter
BCL-2 and Chemoresistance in Cancer
Programmed cell death is a physiological process that plays a critical role in the regulation of tissue homeostasis by ensuring that the rate at which new cells are produced in the body through cell division i...