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  1. No Access

    Article

    The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex

    Shh acts as a survival factor and in its absence its receptor, Patched, induces cell death by recruiting a caspase-activating complex formed by the adaptor protein DRAL, the CARD domain containing proteins TUC...

    Frédéric Mille, Chantal Thibert, Joanna Fombonne, Nicolas Rama… in Nature Cell Biology (2009)

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    Article

    Yeast and apoptosis

    Even though yeast lack much of the molecular machinery that is responsible for apoptosis in metazoans, they can be a powerful tool in apoptosis research. The ectopic expression of several animal apoptosis prot...

    Can **, John C. Reed in Nature Reviews Molecular Cell Biology (2002)

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    Article

    Molecular chaperone targeting and regulation by BAG family proteins

    Regulated changes in protein conformation can have profound effects on protein function, although routine laboratory methods often fail to detect them. The recently discovered BAG-family proteins may operate a...

    Shinichi Takayama, John C. Reed in Nature Cell Biology (2001)

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    Article

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    John C. Reed, Shigemi Matsuyama, Quinn L. Deveraux, Juan Llopis… in Nature Cell Biology (2000)

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    Article

    Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

    Mitochondria trigger apoptosis by releasing caspase activators, including cytochrome c (cytC). Here we show, using a pH-sensitive green fluorescent protein (GFP), that mitochondria-dependent apoptotic stimuli (su...

    Shigemi Matsuyama, Juan Llopis, Quinn L. Deveraux, Roger Y. Tsien… in Nature Cell Biology (2000)

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    Article

    Survivin’ cell-separation anxiety

    Survivin, a cell-death inhibitor, localizes to the spindles of mitotic cells, and its absence causes both a failure in cell division and induction of cell death. Might survivin link the control of cell death w...

    John C. Reed, Steven I. Reed in Nature Cell Biology (1999)