10 Result(s)
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Open AccessHIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2
HIV-1 protease (PR) is essential for viral infectivity as it cleaves Gag and Gag-Pol polyprotein precursors during viral maturation. Recent evidence suggests that cellular proteins can also be cleaved by PR, p...
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Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML
Among the cardinal features of malignancy is abrogation of cell death mechanisms, thus endowing cancer and leukemia cells with a selective survival advantage relative to normal cells. Genetic and epigenetic le...
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Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Perturbations of the endoplasmic reticulum (ER) caused by accumulation of unfolded proteins in this organelle trigger signal-transduction responses that assist...
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Article
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis
The HIPPI (HIP-1 protein interactor) protein is a multifunctional protein that is involved in the regulation of apoptosis. The interaction partners of HIPPI include HIP-1 (Huntingtin-interacting protein-1), Ap...
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Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
Integrity of the blood vessel wall is essential for vascular homeostasis and organ function1,2. A dynamic balance between endothelial cell survival and apoptosis contributes to this integrity during vascular deve...
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Apoptosis and cancer: When BAX is TRAILing away
The development of anticancer therapies that target apoptosis pathways may be hampered by resistance of certain tumor cells to death signals. New findings show that tumor cells lacking the pro-apoptotic protei...
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Apoptosis-based therapies
Physiological cell death, or apoptosis, has an important role in several normal processes, ranging from fetal development to ageing, and defects in the physiol...
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Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy
The time at which ovarian failure (menopause) occurs in females is determined by the size of the oocyte reserve provided at birth, as well as by the rate at which this endowment is depleted throughout post-nat...
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Mitochondrial control of cell death
In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as fo...
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BMD188, A novel hydroxamic acid compound, demonstrates potent anti-prostate cancer effectsin vitro andin vivo by inducing apoptosis: requirements for mitochondria, reactive oxygen species, and proteases
A newly synthesized cyclic hydroxamic acid compound, BMD188 [cis-l-hydroxy-4-(l-naphthyl)-6-oc-tylpiperidine-2-one], was found to induce the apoptotic death of cultured prostate cancer cells by activating casp...
