35 Result(s)

Article

Myocardial glucose suppression may interfere with the detection of inflammatory cells with FDG-PET as suggested in a canine model of myocardial infarction

After myocardial infarction, fibrosis and an ongoing dysregulated inflammatory response have been shown to lead to adverse cardiac remodeling. FDG PET is an imaging modality sensitive to inflammation as long a...

Benjamin Wilk, Haris Smailovic, Rebecca Sullivan, Erik R. Sistermans… in EJNMMI Research (2023)

Article

Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS

Enzymatic cleavage of IgG antibodies is a common strategy used by pathogenic bacteria to ablate immune effector function. The Streptococcus pyogenes bacterium secretes the protease IdeS and the glycosidase EndoS,...

Abigail S. L. Sudol, John Butler, Dylan P. Ivory, Ivo Tews… in Nature Communications (2022)

Article

Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium

Sudden blockage of arteries supplying the heart muscle contributes to millions of heart attacks (myocardial infarction, MI) around the world. Although re-opening these arteries (reperfusion) saves MI patients ...

Ivan Cokic, Shing Fai Chan, **ngmin Guan, Anand R. Nair… in Nature Communications (2022)

Article

Diagnostic routes and time intervals for ovarian cancer in nine international jurisdictions; findings from the International Cancer Benchmarking Partnership (ICBP)

International Cancer Benchmarking Partnership Module 4 reports the first international comparison of ovarian cancer (OC) diagnosis routes and intervals (symptom onset to treatment start), which may inform prev...

Usha Menon, David Weller, Alina Zalounina Falborg… in British Journal of Cancer (2022)

Article

Considerations for multimodal prehabilitation in women with gynaecological cancers: a sco** review using realist principles

There is increasing recognition that prehabilitation is important as a means of preparing patients physically and psychologically for cancer treatment. However, little is understood about the role and optimal ...

Rhia Kaur Saggu, Phillip Barlow, John Butler, Sadaf Ghaem-Maghami… in BMC Women's Health (2022)

Article

Assessment of intramyocardial hemorrhage with dark-blood T2*-weighted cardiovascular magnetic resonance

Intramyocardial hemorrhage (IMH) within myocardial infarction (MI) is associated with major adverse cardiovascular events. Bright-blood T2*-based cardiovascular magnetic resonance (CMR) has emerged as the refe...

**ngmin Guan, Yinyin Chen, Hsin-Jung Yang… in Journal of Cardiovascular Magnetic Resonan… (2021)

Article

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the cell plasma membrane, resul...

Cornelia Blume, Claire L. Jackson, Cosma Mirella Spalluto… in Nature Genetics (2021)

Article

The effect of patient-prosthesis mismatch on survival after aortic and mitral valve replacement: a 10 year, single institution experience

The evidence on the impact of patient-prosthesis Mismatch (PPM) on survival thus far has been conflicting. The aim of this study was to 1) study the effect of PPM on survival after isolated aortic and mitral v...

Sudeep Das De, Ashok Nanjappa, Karim Morcos… in Journal of Cardiothoracic Surgery (2019)

Article

Assessment of a novel 32-channel phased array for cardiovascular hybrid PET/MRI imaging: MRI performance

Cardiovascular imaging using hybrid positron emission tomography (PET) and magnetic resonance imaging (MRI) requires a radio frequency phased array resonator capable of high acceleration factors in order to ac...

Adam Farag, R. Terry Thompson, Jonathan D. Thiessen… in European Journal of Hybrid Imaging (2019)

Article

PROCalcitonin-based algorithm for antibiotic use in Acute Pancreatitis (PROCAP): study protocol for a randomised controlled trial

Differentiating infection from inflammation in acute pancreatitis is difficult, leading to overuse of antibiotics. Procalcitonin (PCT) measurement is a means of distinguishing infection from inflammation as le...

Ajith K. Siriwardena, Santhalingam Jegatheeswaran, James M. Mason… in Trials (2019)

Article

Fast, heart-rate independent, whole-heart, free-breathing, three-dimensional myocardial BOLD MRI at 3T with simultaneous ¹³N-ammonia PET validation in canines

Hsin-Jung Yang, Damini Dey, Jane M Sykes… in Journal of Cardiovascular Magnetic Resonan… (2016)

Article

Towards reliable myocardial blood-oxygen-level-dependent (BOLD) CMR using late effects of regadenoson with simultaneous ¹³n-ammonia pet validation in a whole-body hybrid PET/MR system

Hsin-Jung Yang, Damini Dey, Jane M Sykes… in Journal of Cardiovascular Magnetic Resonan… (2016)

Article

Role of topical application of iced slush in the development of phrenic nerve palsy after cardiac surgery

Ahmed Oliemy, Sanjeet Singh, John Butler in Journal of Cardiothoracic Surgery (2015)

Article

'What did the doctor say again?' - Patient Expectations Prior To Cardiac Surgery

Michael MacPherson, Gwyn Beattie, John Butler… in Journal of Cardiothoracic Surgery (2015)

Article

Management of New Post-Operative Arrhythmia in Cardiac Patients

Michael MacPherson, Gwyn Beattie, Robyn Smith… in Journal of Cardiothoracic Surgery (2015)

Article

Is England closing the international gap in cancer survival?

We provide an up-to-date international comparison of cancer survival, assessing whether England is ‘closing the gap’ compared with other high-income countries.

Sarah Walters, Sara Benitez-Majano, Patrick Muller… in British Journal of Cancer (2015)

Article

Preliminary evaluation of MRI-derived input function for quantitative measurement of glucose metabolism in an integrated PET-MRI

Udunna Anazodo, Matthew Kewin, Elizabeth Finger, Jonathan Thiessen… in EJNMMI Physics (2015)

Article

How to make an aortic root replacement simulator at home

There is a paucity of low-fidelity and cost-efficient simulators for training cardiac surgeons in the aspects of aortic root/valve replacement. In this study we addressed this training challenge by creating a ...

Kasra Shaikhrezai, Maziar Khorsandi… in Journal of Cardiothoracic Surgery (2015)

Article

Whole-heart, free-breathing, three-dimensional myocardial BOLD MRI at 3T with simultaneous ¹³N-ammonia PET in canines

Hsin-Jung Yang, Damini Dey, Jane Sykes… in Journal of Cardiovascular Magnetic Resonan… (2015)