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  1. Article

    Open Access

    Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium

    Sudden blockage of arteries supplying the heart muscle contributes to millions of heart attacks (myocardial infarction, MI) around the world. Although re-opening these arteries (reperfusion) saves MI patients ...

    Ivan Cokic, Shing Fai Chan, **ngmin Guan, Anand R. Nair… in Nature Communications (2022)

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  2. Article

    Open Access

    NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

    Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy. However, molecular mechan...

    Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela… in Nature Communications (2017)

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  3. Article

    Open Access

    S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease

    Mutations in the gene encoding parkin, a neuroprotective protein with dual functions as an E3 ubiquitin ligase and transcriptional repressor of p53, are linked to familial forms of Parkinson’s disease (PD). We...

    Carmen R Sunico, Tomohiro Nakamura, Edward Rockenstein… in Molecular Neurodegeneration (2013)

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  4. No Access

    Article

    The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication

    Emerging evidence suggests that supernumerary centrosomes drive genome instability and oncogenesis1,2,3. Human T-cell leukaemia virus type I (HTLV-I) is etiologically associated with adult T-cell leukaemia (ATL)4

    Yick-Pang Ching, Shing-Fai Chan, Kuan-Teh Jeang, Dong-Yan ** in Nature Cell Biology (2006)