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Open AccessNew indications for the life habits of long-legged aphidlion-like larvae in about 100-million-year-old amber
Larvae of lacewings (Neuroptera) are known to be fierce predators today. Most characteristic are their prominent piercing-sucking stylets, which are used for venom injection and sucking out the fluids of the p...
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Article
Open AccessSafety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myo...
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Open AccessElateriform beetle larvae preserved in about 100-million-year-old Kachin amber
Beetle larvae show high diversity in forms and ecological roles. Beetle larvae are often roughly categorised into certain larval types, for example: campodeiform, onisciform, scarabeiform, or elateriform. Larv...
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Article
Open AccessZebrafish nampt-a mutants are viable despite perturbed primitive hematopoiesis
Nicotinamide phosphoribosyltransferase (Nampt) is required for recycling NAD+ in numerous cellular contexts. Morpholino-based knockdown of zebrafish nampt-a has been shown to cause abnormal development and defect...
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Article
High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities
The human gut microbiome is a key contributor to health, and its perturbations are linked to many diseases. Small-molecule xenobiotics such as drugs, chemical pollutants and food additives can alter the microb...
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Hungary, the EU and Russia’s War Against Ukraine: The Changing Dynamics of EU Foreign Policymaking
The Hungarian government led by the populist radical right (PRR) Fidesz party, which came to power in 2010, soon gained a reputation for reorganizing domestic state institutions in line with its illiberal poli...
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Open AccessTemperature to time Catch-Up: a novel procedural endpoint to predict durable pulmonary vein isolation after cryoballoon ablation of paroxysmal atrial fibrillation
Cryoballoon ablation is a widely used single-shot technique for pulmonary vein isolation (PVI) in the treatment of paroxysmal atrial fibrillation (AF). Procedural endpoints ensuring maximal PVI durability are ...
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Open AccessUncovering developmental time and tempo using deep learning
During animal development, embryos undergo complex morphological changes over time. Differences in developmental tempo between species are emerging as principal drivers of evolutionary novelty, but accurate de...
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Open AccessUnusual larviform beetles in 100-million-year-old Kachin amber resemble immatures of trilobite beetles and fireflies
Despite the large number of species in the group Coleoptera (beetles), it is usually relatively easy to identify an adult beetle as such due to certain common characteristics. Among beetle larvae, however, the...
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Open AccessUser needs over time: the market and technology maturity model (MTMM)
This paper conceptualizes how consumers perceive innovations at different stages of technology maturity. The market and technology maturity model (MTMM) combines the constructs of acceptability, acceptance, an...
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Open AccessEmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways
Evolutionarily conserved signaling pathways are essential for early embryogenesis, and reducing or abolishing their activity leads to characteristic developmental defects. Classification of phenotypic defects ...
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Open AccessThe first fossil false click beetle larva preserved in amber
We report a new and unusual beetle larva preserved in ca. 100 million-year-old Kachin amber. Larvae of many modern lineages of beetles are associated with wood, breaking it into smaller pieces or directly dige...
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A Molecular Biomarker-Based Triage Approach for Targeted Treatment of Post-COVID-19 Syndrome Patients with Persistent Neurological or Neuropsychiatric Symptoms
Approximately 30% of COVID-19 cases may experience chronic symptoms, known as post-COVID-19 syndrome (PCS). Common PCS symptoms can include fatigue, cognitive impairment, and persistent physical, neurological,...
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Left atrial appendage closure in patients with intracranial hemorrhage: the clock is ticking — to take the bull by the horn or wait for a randomized controlled trial
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Open AccessDeclining morphological diversity in snakefly larvae during last 100 million years
Raphidioptera, the group of snakeflies, is a rather species-poor in-group of Holometabola. Yet, fossils of snakeflies indicate that the group was more diverse in the past. Here we compare the morphological div...
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Article
Light-sheet 3D microprinting via two-colour two-step absorption
High-speed high-resolution 3D printing of polymers is highly desirable for many applications, yet still technologically challenging. Today, optics-based printing is in the lead. Projection-based linear optical...
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Open AccessSingle-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model
The hindered diffusion model postulates that the movement of a signaling molecule through an embryo is affected by tissue geometry and binding-mediated hindrance, but these effects have not been directly demon...
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Open AccessPeptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
The transmembrane serine protease 2 (TMPRSS2) primes the SARS-CoV-2 Spike (S) protein for host cell entry and represents a promising target for COVID-19 therapy. Here we describe the in silico development and ...
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Open AccessDebris-carrying behaviour of bark lice immatures preserved in 100 million years old amber
Camouflage strategies, including several types of concealments, are known for several insect groups today, such as immatures of some species within reduviid bugs (Hemiptera), lace wings (Neuroptera), caddisfli...
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Open AccessFirst fossil tumbling flower beetle-type larva from 99 million-year-old amber
Beetle larvae often differ significantly in morphology from their adult counterparts. Therefore, it should be surprising that these immatures are often not considered to the same extent as the adult beetles. A...
