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Article
Open AccessPossibilities and efficiency of MSC co-transfection for gene therapy
Mesenchymal stem/stromal cells (MSCs) are not only capable of self-renewal, trans-differentiation, homing to damaged tissue sites and immunomodulation by secretion of trophic factors but are also easy to isola...
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Article
Open AccessInk-structing the future of vascular tissue engineering: a review of the physiological bioink design
Three-dimensional (3D) printing and bioprinting have come into view for a plannable and standardizable generation of implantable tissue-engineered constructs that can substitute native tissues and organs. Thes...
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Article
Open AccessLow impact of regular PCR testing on presence at work site during the COVID-19 pandemic: experiences during an open observational study in Lower Saxony 2020-21
Since social distancing during the COVID-19-pandemic had a profound impact on professional life, this study investigated the effect of PCR testing on on-site work.
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Article
Open AccessSigns of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is effective in preventing COVID-19 hospitalization and fatal outcome. However, several studies indicated that there is reduced ...
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Article
A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection
Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the cell plasma membrane, resul...
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Article
Open AccessEngineering multi-layered tissue constructs using acoustic levitation
Engineering tissue structures that mimic those found in vivo remains a challenge for modern biology. We demonstrate a new technique for engineering composite structures of cells comprising layers of heterogeneous...
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Chapter
Die künstliche Niere: Eine Zukunftsvision und ihre Marktfähigkeit
„Tissue Engineered Products“ gelten als Wegbereiter für die Entwicklung komplexer künstlicher Organe, und die biomedizinische Forschung in diesem Bereich boomt. Nichtsdestotrotz ist die Situation hinsichtlich ...
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Article
Analyse des Mikromilieus künstlicher Gewebe mit Protein-Multiplex-Assays
The development of bioartificial tissues using stem cells has an enormous potential in medicine. To determine effects of differentiation strategies on cell micro-milieus, a fast and efficient method is necessa...
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Article
Hydrogels for 3D mammalian cell culture: a starting guide for laboratory practice
Hydrogels have become one of the most popular platforms for three-dimensional (3D) cultivation of mammalian cells. The enormous versatility of hydrogel materials makes it possible to design scaffolds with pred...
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Article
Open AccessEffects of ultrafine particles-induced oxidative stress on Clara cells in allergic lung inflammation
Clara cell protein (CC16), the main secretory product of bronchiolar Clara cells, plays an important protective role in the respiratory tract against oxidative stress and inflammation. The purpose of the study...
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Article
Die Ciguatera-Vergiftung
In tropischen Meeren kommen karnivore Speisefische wie der Zackenbarsch vor, die bestimmte toxinbildende Algen enthalten und eine Ciguatera-Vergiftung auslösen könne. Wegen des gehäuften Fernreisetourismus in ...
