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Article
Impact of metabolic factors on risk of cardiovascular disease in nondiabetic metabolic dysfunction-associated fatty liver disease
Changing terminology of non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated fatty liver disease (MAFLD) is recently proposed by expert panels based on metabolic dysregulations. Howeve...
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Article
Impact of Agarose Hydrogels as Cell Vehicles for Neo Retinal Pigment Epithelium Formation: In Vitro Study
Retinal pigment epithelium (RPE) which plays a key role of the visual function is destroyed by retinal diseases, which are affected to visual impairment or blindness. Agarose (Agr) prepared from Marine red alg...
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Article
Biomimetic Calcium Phosphate Coated Macro-Microporous Poly(ε-caprolactone)/Silk Fibroin (PCL/SF) Scaffold for Bone Tissue Engineering
Because of an aging population and social development, tissue engineering techniques have been widely studied and used for patient treatment. To improve bone regeneration and overcome disadvantages, suitable b...
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Article
Evaluation of calcium phosphate–coated polycaprolactone/graphene oxide scaffold with macro- and microporous structure for bone tissue engineering
This study aimed to fabricate porous PCL/GO scaffolds by adding graphene oxide (GO) which is a hydrophilic material to improve cell affinity of PCL. Calcium phosphate (CaP) coating was performed to enhance the...
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Article
Characterization of Taurine/Silk Fibroin Blend Film for Application as a Carrier for Corneal Endothelial Cell Transplantation
Corneal endothelial cells (CEnCs) cannot be regenerated once damaged, so restoring corneal function can only be achieved through tissue engineering. In this study, biocompatible films were prepared from silk f...
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Article
Characterization of non-solvent- and thermal-induced phase separation applied polycaprolactone/demineralized bone matrix scaffold for bone tissue engineering
Polycaprolactone (PCL) is a widely applied biomaterial in bone tissue engineering (BTE) due to its superior mechanical properties and biodegradability. However, the high hydrophobicity and low cell adhesion pr...
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Article
Enhanced Silk Fibroin-Based Film Scaffold Using Curcumin for Corneal Endothelial Cell Regeneration
The high demand for transplantable corneas is unlikely to subside anytime soon as there is a persistent shortage of cadaveric cornea. The goal of this study was to fabricate film scaffolds with desirable prope...
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Article
Improvement of Medication Adherence and Controlled Drug Release by Optimized Acetaminophen Formulation
Acetaminophen (paracetamol, APAP) is a major component of Tylenol, Penzal Q, and Panpyrin, and is the most commonly used antipyretic analgesic in children. The conventional oral drug delivery systems of APAP a...
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Article
Release Behavior of Telmisartan/Amlodipine Combination Drug According to Polymer Type
Patients at risk for hypertension with comorbidities such as diabetes and metabolic syndrome often require two or more antihypertensive drugs to lower their blood pressure. Telmisartan and amlodipine are widel...
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Article
Characterization of Platelet-Rich Plasma/Gellan Gum Hydrogel Composite for Biological Performance to Induce Chondrogenesis from Adipose-Derived Stem Cells
In this experiment, hydrogel composite was developed with gellan gum (GG) and platelet-rich plasma (PRP) to induce chondrogenesis of adipose-derived stem cells (ADSCs) in the hydrated environment. FTIR, SEM, a...
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Article
Evaluation of Hyaluronic Acid/Agarose Hydrogel for Cartilage Tissue Engineering Biomaterial
Hyaluronic acid (HA) is one of the most applied biomaterials in a tissue engineering field due to its biocompatibility and its presence in the native extracellular matrix (ECM) of tissues. However, the mechani...
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Article
Sustained-Released Formulation of Nifedipine Solid Dispersion with Various Polymers
Nifedipine is a calcium channel blocker widely used for the treatment of blood pressure related diseases such as angina, hypertension and Raynaud. However, since the drug after the administration reaches the h...
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Article
Alleviated Side Effects and Improved Efficiency of Omeprazole Using Oral Thin Film: In Vitro Evaluation
Omeprazole (OM), typically used for patients with gastric problems, is a proton pump inhibitor, which reduces the amount of stomach acid production effectively by regulating the proton pump. However, the main ...
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Article
Fabrication of POX/PLGA Scaffold for the Potential Application of Tissue Engineering and Cell Transplantation
Poly lactic-co-glycolic acid (PLGA), a synthetic polymer, belongs to the fabrication of poly(α-hydroxy acid) systems approved by the US Food and Drug Administration. PLGA has been widely used in clinical appli...
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Chapter
Bone Regeneration Using Duck’s Feet-Derived Collagen Scaffold as an Alternative Collagen Source
Collagen is an important component that makes 25–35% of our body proteins. Over the past decades, tissue engineers have been designing collagen-based biocompatible materials and studying their applications in ...
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Chapter
Enhancing Osteochondral Tissue Regeneration of Gellan Gum by Incorporating Gallus gallus var Domesticus-Derived Demineralized Bone Particle
Treatment for the osteochondral defects (ODs) is more challenging nowadays that needs to be addressed by develo** alternative bone tissue engineering materials. Gellan gum (GG) is a widely used natural polys...
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Article
UV-Irradiated RPE Cells Assist Differentiation of Bone Marrow Derived Mesenchymal Stem Cells into RPE Cells Under a Direct Co-Culture Environment
Degeneration of retinal pigment epithelium cells (RPE) or delamination of RPE from Bruch’s membrane causes visual impairment. While regeneration of RPE cells is desirable to treat age-related macular degenerat...
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Article
Evaluation of Cartilage Regeneration in Gellan Gum/agar Blended Hydrogel with Improved Injectability
Gellan gum is known to be one of the biocompatible materials that resemble living tissues, continuously delivering stem cells or general cells, and filling voids in the wound. In spite of the many advantages o...
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Article
Evaluation of Chondrogenic Differentiation Ability of Bone Marrow Mesenchymal Stem Cells in Silk Fibroin/Gellan Gum Hydrogels Using miR-30
The poor proliferative ability of chondrocytes makes complicated the cartilage regeneration after injuries or during the pathological state. Nowadays, stem cells represent a potential tool for different tissue...
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Article
Improved Rapid Action of Dapoxetine Hydrochloride & L-arginine Solid Dispersion Using Film Formulation
Dapoxetine Hydrochloride (DH) have been developed for the treatment of premature ejaculation for men. DH promotes the ejaculatory delay as the selective serotonin inhibitor. However, it is necessary to delay t...
