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Article
Open AccessProteomic profiling of extracellular vesicles derived from human serum for the discovery of biomarkers in Avascular necrosis
Avascular necrosis (AVN) is a medical condition characterized by the destruction of bone tissue due to a diminished blood supply. When the rate of tissue destruction surpasses the rate of regeneration, effecti...
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Article
Effect of modification methods on the physical properties and immunomodulatory activity of particulate β-glucan
β-Glucan is an immunoenhancing agent whose biological activities are linked to molecular structure. On that basis, the polysaccharide can be physiochemically modified to produce valuable functional materials. ...
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Article
Extracellular Vesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells Suppress RANKL-Induced Osteoclast Differentiation via miR122-5p
Researchers are increasingly interested in cell therapy using mesenchymal stem cells (MSCs) as an alternative remedy for osteoporosis, with fewer side effects. Thus, we isolated and characterized extracellular...
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Article
Biomimetic Calcium Phosphate Coated Macro-Microporous Poly(ε-caprolactone)/Silk Fibroin (PCL/SF) Scaffold for Bone Tissue Engineering
Because of an aging population and social development, tissue engineering techniques have been widely studied and used for patient treatment. To improve bone regeneration and overcome disadvantages, suitable b...
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Article
Evaluation of calcium phosphate–coated polycaprolactone/graphene oxide scaffold with macro- and microporous structure for bone tissue engineering
This study aimed to fabricate porous PCL/GO scaffolds by adding graphene oxide (GO) which is a hydrophilic material to improve cell affinity of PCL. Calcium phosphate (CaP) coating was performed to enhance the...
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Article
Characterization of Taurine/Silk Fibroin Blend Film for Application as a Carrier for Corneal Endothelial Cell Transplantation
Corneal endothelial cells (CEnCs) cannot be regenerated once damaged, so restoring corneal function can only be achieved through tissue engineering. In this study, biocompatible films were prepared from silk f...
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Article
Characterization of non-solvent- and thermal-induced phase separation applied polycaprolactone/demineralized bone matrix scaffold for bone tissue engineering
Polycaprolactone (PCL) is a widely applied biomaterial in bone tissue engineering (BTE) due to its superior mechanical properties and biodegradability. However, the high hydrophobicity and low cell adhesion pr...
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Article
Enhanced Silk Fibroin-Based Film Scaffold Using Curcumin for Corneal Endothelial Cell Regeneration
The high demand for transplantable corneas is unlikely to subside anytime soon as there is a persistent shortage of cadaveric cornea. The goal of this study was to fabricate film scaffolds with desirable prope...
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Article
Open AccessCombination of vegetable soup and glucan demonstrates synergistic effects on macrophage-mediated immune responses
Vegetable soup (VS), a plant-based functional food, has been used as a traditional folk medicine and is attracting attention for its ability to enhance the immune response. β-Glucan, a well-established and eff...
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Article
Characterization of Platelet-Rich Plasma/Gellan Gum Hydrogel Composite for Biological Performance to Induce Chondrogenesis from Adipose-Derived Stem Cells
In this experiment, hydrogel composite was developed with gellan gum (GG) and platelet-rich plasma (PRP) to induce chondrogenesis of adipose-derived stem cells (ADSCs) in the hydrated environment. FTIR, SEM, a...
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Article
Open AccessA comparative study of the phenotype with kainic acid-induced seizure in DBA/2 mice from three different sources
The kainic acid-induced seizure mouse model is widely used in epilepsy research. In this study, we applied kainic acid to the subcutaneous injections of three different sources of DBA/2 mice to compare and eva...
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Article
Evaluation of Hyaluronic Acid/Agarose Hydrogel for Cartilage Tissue Engineering Biomaterial
Hyaluronic acid (HA) is one of the most applied biomaterials in a tissue engineering field due to its biocompatibility and its presence in the native extracellular matrix (ECM) of tissues. However, the mechani...
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Application of Gellan Gum-Based Scaffold for Regenerative Medicine
Gellan gum (GG) is a linear microbial exopolysaccharide which is derived naturally by the fermentation process of Pseudomonas elodea. Application of GG in tissue engineering and regeneration medicine (TERM) is al...
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Article
Open AccessNucleotide-binding oligomerization domain 1 is dispensable for host immune responses against pulmonary infection of Acinetobacter baumannii in mice
Nucleotide-binding domain 1 (Nod1) is a cytosolic receptor that is responsible for the recognition of a bacterial peptidoglycan motif containing meso-diaminophimelic acid. In this study, we sought to identify the...
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Article
Evaluation of Saponin Loaded Gellan Gum Hydrogel Scaffold for Cartilage Regeneration
Several concentrations of saponin (Sa), which is water-soluble, were fabricated well with gellan gum (GG) solution. Sa, found in many plants like clematis and ginseng, has long been used in traditional chinese...
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Article
Open AccessPRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice
Protein arginine methylation is a novel form of posttranslational modification mediated by protein arginine methyltransferase (PRMTs). PRMT1, a major isoform of the PRMT family, is responsible for various biol...
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Chapter
Silk Fibroin-Based Scaffold for Bone Tissue Engineering
Regeneration of diseased or damaged skeletal tissues is one of the challenge that needs to be solved. Although there have been many bone tissue engineering developed, scaffold-based tissue engineering compleme...
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Article
Open AccessImmunomodulatory effects of ethanol extract of germinated ice plant (Mesembryanthemum crystallinum)
The purpose of this study was to investigate the immunomodulatory activity of ice plant (Mesembryanthemum crystallinum) extract (IPE) in vitro and in vivo. Raji (a human B cell line) and Jurkat (a human T cell li...
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Article
Lactobacillus curvatus WiKim38 isolated from kimchi induces IL-10 production in dendritic cells and alleviates DSS-induced colitis in mice
Probiotics such as lactobacilli and bifidobacteria have healthpromoting effects by immune modulation. In the present study, we examined the immunomodulatory properties of Lactobacillus curvatus WiKim38, which was...
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Article
Effects of brown rice diets inoculated with Lactobacillus sakei Wikim001 having phytase activity on the osteoporosis in ovariectomized mice model
The present study examined the preventive effect of osteoporosis in ovariectomized (OVX) mice by feeding of phytate-reduced brown rice inoculated with the selected Lactobacillus sakei Wikim001 having high phytase...
