3 Result(s)
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Jamie A. Moroco
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAllosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification of PPM1D are found across numerous cancer types. GSK...
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Article
Open AccessStructural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency
Very long-chain acyl-CoA dehydrogenase (VLCAD) is an inner mitochondrial membrane enzyme that catalyzes the first and rate-limiting step of long-chain fatty acid oxidation. Point mutations in human VLCAD can p...
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Article
Open AccessAllosteric control of Ubp6 and the proteasome via a bidirectional switch
The proteasome recognizes ubiquitinated proteins and can also edit ubiquitin marks, allowing substrates to be rejected based on ubiquitin chain topology. In yeast, editing is mediated by deubiquitinating enzym...
