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  1. No Access

    Article

    Selective depletion of marrow-T cytotoxic lymphocytes (CD8) in the prevention of graft-versus-host disease after allogeneic bone-marrow transplantation

    In vitro depletion of mature pan-T lymphocytes has been widely and successfully used to prevent acute graft-versus-host disease (GVHD) after allogeneic bone-marrow transplantation (BMT). However, this procedur...

    D. Maraninchi, C. Mawas, D. Guyotat, J. Reiffers, J. P. Vernant in Transplant International (1988)

  2. No Access

    Chapter and Conference Paper

    Treatment of Relapsed or Refractory Acute Leukemia: Comparison of Two Different Regimens

    The treatment of relapsed or refractory acute leukemia (AL) remains problematic. The use of high-dose cytosine arabinoside (HD Ara-C) appears promising [1] and its association with M-amsacrine (M-AMSA) has ach...

    G. Marit, P. Cony, F. Duclos, M. Puntous, A. Broustet, J. Reiffers in Acute Leukemias II (1990)

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    Chapter and Conference Paper

    Incomplete Stroma Formation by Bone Marrow from Chronic Myeloid Leukemia Patients Treated with Interferon

    Chronic myeloid leukemia (CML) results from the neoplastic transformation of a pluripotent stem cell. The disease is characterized by a significantly increased number of granulo-monocytic progenitors in both t...

    A. Rice, J. Reiffers, Ph. Bernard, C. Foures in Cytokines in Hemopoiesis, Oncology, and AI… (1990)

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    Chapter

    Purged Autologous Bone Marrow: Better or Worse than Circulating Stem Cells?

    Autologous bone marrow tranplantation (ABMT) has been extensively used as treatment for hematological malignancies over the last decade [1]. The main cause of failure after ABMT is relapse or recurrence of the...

    J. Reiffers in Advances in haemapheresis (1991)

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    Article

    Anti-LFA1 monoclonal antibody (25.3) for treatment of steroid-resistant grade III–IV acute graft-versus-host disease

    The in vivo efficacy of 25.3 monoclonal antibody (mAb) directed against human LFA1 molecule was assessed in ten patients with steroid-resistant grade III–IV acute graft-versus-host disease (AGVHD). These patie...

    A. M. Stoppa, D. Maraninchi, D. Blaise, P. Viens, M. Hirn in Transplant International (1991)

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    Chapter and Conference Paper

    Possible Effect of Autologous Blood Stem Cell Transplantation on Outcome of Acute Myeloid Leukemia in First Relapse

    Despite recent progress in the treatment of acute myelogenous leukemia (AML), most patients who achieve complete remission (CR) relapse within 2 years following induction chemotherapy. In some of these latter ...

    J. Reiffers, G. Marit, P. Cony-Makhoul, C. Faberes, P. Fernandez in Acute Leukemias (1992)

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    Chapter and Conference Paper

    Prospective Study Comparing Idarubicin and Daunorubicin in Elderly Patients with Acute Myeloid Leukemia

    There is general agreement about the use of a combination of cytosine arabinoside (Ara-C) and anthracycline as induction chemotherapy for patients with acute myeloid leukemia (AML). Cytosine arabinoside is usu...

    J. Reiffers, F. Rigal-Huguet, A. M. Stoppa, M. Michallet, G. Marit in Acute Leukemias (1992)

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    Chapter and Conference Paper

    Use of Recombinant Interleukin-2 (RU 49637) After Autologous Bone Marrow Transplantation in Patients with Hematological Disease: Phase I–II Study

    Allogeneic bone marrow transplantation (BMT) is currently an established therapy for hematological malignancies. Twenty years of experience has demonstrated that curability comes from both tumor ablation due t...

    D. Blaise, D. Olive, M. Brandely in Cytokines in Hemopoiesis, Oncology, and AI… (1992)

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    Chapter and Conference Paper

    Treatment of Relapsed Acute Myeloid Leukemia with Granulocyte-Macrophage Colony-Stimulating Factor and Intensive Chemotherapy

    The treatment of relapsed acute myeloid leukemia (AM L) often involves the use of high-dose cytosine arabinoside (ara-C) [10]. The combination of ara-C and amsacrine gives good results [3], permitting a comple...

    M. Puntous, F. Lacombe, G. Marit, P. Dumain in Cytokines in Hemopoiesis, Oncology, and AI… (1992)

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    Chapter and Conference Paper

    Toxicity Profile of Idarubicin: Experiences with Oral and Intravenous Idarubicin in the Treatment of Leukemia

    Idarubicin (IDR) is a new potent antileukemic agent and the only anthracycline derivative in current use that can be administered orally. We review here the French experience with oral and IV IDR.

    J. L. Harousseau, B. Pignon, J. Reiffers, F. Rigal-Huguet, J. Y. Cahn in Acute Leukemias (1992)

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    Chapter and Conference Paper

    The In Vitro Effect of Interferon-γ on Chronic Myeloid Leukemia Cells

    Chronic myeloid leukemia (CM L) results from the neoplastic transformation of a pluripotent hematopoietic stem cell [1]. At present the only curative treatment for this disease is an allogeneic bone marrow tra...

    A. Rice, M. Becker, G. Marit, P. Bernard in Cytokines in Hemopoiesis, Oncology, and AI… (1992)

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    Chapter and Conference Paper

    Bone Marrow Transplantation for Chronic Myeloid Leukemia in France. Results of the French Cooperative Group

    Transplants were performed in 281 patients (pts) with chronic myeloid leukemia (CML) in France between 1979 and 1986. The actuarial survival after 5 years is 55% for the patients receiving grafts in first chro...

    A. Devergie, J. Reiffers, J. P. Vernant, P. Hérvé, D. Guyotat, D. Maraninchi in Leukemias (1993)

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    Chapter

    The Use of Long-Term Culture Techniques to Study Peripheral Blood Stem Cells Before and After Autologous Transplantation

    Autologous blood stem cells collected during the recovery phase after intensive chemotherapy are rich in progenitor cells, and, when infused into patients who have received myeloablative therapy, lead to rapid...

    A. Rice, C. Foures, P. Bernard, G. Marit in Peripheral Blood Stem Cell Autografts (1993)

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    Chapter and Conference Paper

    Recombinant Human Erythropoietin After Bone Marrow Transplantation — A Placebo Controlled Trial

    Several historically controlled studies [1,3,5] and one small open prospective randomized trial [4] showed an acceleration of erythropoietic recon-stitution after allogeneic bone marrow transplantation (BMT). ...

    H. Link, M. A. Boogaerts, A. Fauser, R. Or, J. Reiffers, N. C. Gorin in Acute Leukemias V (1996)

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    Chapter and Conference Paper

    IL2 in Acute Leukemia

    Immunotherapy is a logical approach for the strategy of a currative treatment for acute leukemia since allogeneic bone marrow transplantation had demonstrated the benefit of graft versus host disease (GVHD) to...

    D. Blaise, A. M. Stoppa, M. Attal, J. Reiffers, J. Fleury in Acute Leukemias V (1996)

  16. No Access

    Article

    Correction of the enzyme deficit of bone marrow cells in congenital erythropoietic porphyria by retroviral gene transfer

    F. Moreau-Gaudry, C. Barbot, F. Mazurier, F. X. Mahon in Hematology and Cell Therapy (1996)

  17. No Access

    Article

    Blood cell transplantation: past, present and future

    Blood cell transplantation is rapidly replacing bone marrow transplantation for restoration of hematopoiesis after high-dose chemotherapy in both the autologous and allogeneic settings. Future developments of ...

    J. M. Boiron, J. Reiffers, R. M. Lowenthal in Hematology and Cell Therapy (1996)

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    Chapter and Conference Paper

    Peripheral Blood Stem Cell Transplantation in Acute Myeloid Leukemia

    Autologous peripheral blood stem cell (PBSC) transplantation was first successfully performed in patients with acute myelogenous leukemia (AML) during the mid 1980s. Since these reports [1-3], the number of pa...

    J. Reiffers, J.-M. Boiron, P. Cony-Makhoul, G. Marit, F.-X. Mahon in Acute Leukemias VI (1997)

  19. No Access

    Chapter and Conference Paper

    Allogeneic and Autologous Bone Marrow Transplantation and Chemotherapy in First Remission of Adult Acute Lymphoblastic Leukemia: Results of the LALA 87 Trial of the French Group

    In a prospective study of 317 acute lymphoblastic leukemia (ALL) patients aged 15–40 years and in complete remission, 257 had a potential donor and one HLA ty** analysis; A total of 116 patients were allocat...

    D. Fière, J. P. Vernant, J. Reiffers, J. M. Miclea, F. Witz in Acute Leukemias VI (1997)

  20. No Access

    Article

    Plasma cytokines in graft vs host disease and complications following bone marrow transplantation

    A cohort of 201 autologous or allogeneic bone marrow transplanted (BMT) patients were included for studying the evolution of circulating tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) by mean...

    A. N. Abdallah, J. M. Boiron, Y. Attia, A. Cassaigne in Hematology and Cell Therapy (1997)

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