Abstract
The treatment of relapsed or refractory acute leukemia (AL) remains problematic. The use of high-dose cytosine arabinoside (HD Ara-C) appears promising [1] and its association with M-amsacrine (M-AMSA) has achieved some encouraging results [2]. Such an association permits one to achieve a substantial number of complete remissions (CRs) but the median duration of these CRs remains short and other protocols including new drugs such as mitoxantrone alone [3], or in combination with other drugs are needed [4-6]. The association of mitoxantrone and etoposide (VP-16) appears to be active in acute nonlymphoblastic leukemia [4]. We report here the results observed in relapsed or refractory AL with two consecutive but dif-ferent regimens combining either HD Ara-C-M-AMSA or mitoxantrone-VP-16.
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References
Herzig H, Wolff N, Lazarius M, Philip L, Karanes C, Herzig P (1983) High-dose cytosine-arabinoside therapy for refractory leukemia. Blood 62: 361 - 369
Arlin ZA, Ahmed T, Mitellmann A, Feldman E, Mehta R, Weinstein P, Rieber E, Sullivan P, Baskind P (1987) A new regimen of amsacrine and high-dose cytarabine is safe and effective therapy for acute leukemia. J Clin Oncol 5: 371 - 375
Bernasconi C, Lazzarino M, Bezwoda NR, De Bock R, Hutchinson R, Mandelli F, Windfield DA (1987) Mitoxantrone as single agent in refractory acute leukemia: a multiin-stitutional study (Abstract 121). 4th International Symposium on Therapy of acute leukemias. Rome, 7-12 February 1987
Ho AD, Lipp T, Ehninger G, Illiger HJ, Meyer P, Freund M, Hunstein W (1988) Combination of mitoxantrone and etoposide in refractory acute myelogenous leukemia. An active and well-tolerated regimen. J Clin Oncol 6: 213-217
Tschopp L, Von Fliedner VE, Sauter C, Maurice P, Gratwohl A, Fopp M, Cavalli F (1986) Efficacy and clinical cross-resistance of a new combination therapy (AMSA/VP 16) in previously treated patients with acute non lymphocytic leukemia. J Clin Oncol 4: 318 - 324
Hiddeman W, Kreutzmann H, Straif K, Ludwig WD, Donhunysten Ant R, Engfelder E, Arlin Z, Buchner T (1986) High-dose cytosine-arabinoside and mitoxantrone in re-fractory acute myeloid leukemia: a clinical phase I/II study. Onkologie 9: 144 - 148
Yates J, Glidewell O, Wierneck P, Cooper MR, Steinberg D, Dosik H, Levy R, Hoagland C, Henry P, Gottlieb A, Conell C, Berenberg J, Hutchison JL, Karch P, Nissen N, Ellison RR, Frelich R, Watson JG, Falkson G, Silver RT, Ohaurani F, Green M, Henderson E, Leone L, Hollands JF (1982) Cytosine-arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia. CALGB study. Blood 60: 454-459
Miller AB, Hoogstraten B, Staquet M (1981) Reporting results of cancer treatment. Cancer 47: 207 - 214
Marit G, David B, Reiffers J, Broustet A (1985) Traitement des leucemies aigiies myeloides par amsacrine et hautes doses de cytosine arabinoside: essai phase II. Bull Cancer 72: 37 - 41
Larson R, Preisler H, Azarma N, Benett J, Browman G, Goldberg J, Gottlieb A, Grunwald H, Krishner J, Miller R, Priore R, Raza A, Verkh L, Vogler R, Winton E (1988) Selective use of amsa following high dose Ara-C for patients with acute non lymphoblastic leukemia in first relapse. Proceedings of ASCO. J Clin Oncol 7: 698
Lazzarino M, Morra E, Alessandrino EP, Bernasconi P, Merante S, Inveraudi D, Bonfichi M, Bernasconi C (1988) Mitoxantrone-etoposide combination chemotherapy for re-lapsed and refractory acute myeloid leukemia in adults. Thirtieth annual meeting of American Society of Hematology. San Antonio. 3-6 December 1987. Blood 72 [Suppl 1]: 212 (Abstract 751)
Letendre L, Hinemann V, Hoagland HC, Kovach JS (1985) Phase I study of VP-16 and amsacrine in the treatment of refractory acute leukemia. Med Ped Oncol 13: 232 - 234
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© 1990 Springer-Verlag Berlin Heidelberg
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Marit, G., Cony, P., Duclos, F., Puntous, M., Broustet, A., Reiffers, J. (1990). Treatment of Relapsed or Refractory Acute Leukemia: Comparison of Two Different Regimens. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_112
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DOI: https://doi.org/10.1007/978-3-642-74643-7_112
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