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Article
Randomized study of early hospital discharge following autologous blood SCT: medical outcomes and hospital costs
We report the first randomized study comparing early hospital discharge with standard hospital-based follow-up after high-dose chemotherapy (HDCT) and PBSCT. Patients aged 18–65 years, with an indication of PB...
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Article
A phase II trial of rituximab as adjuvant to intensive sequential chemotherapy in patients under 60 years with untreated poor-prognosis diffuse large B-cell lymphoma
The potential benefit of rituximab as adjuvant to high-dose therapy (HDT) has been investigated in patients under 60 years with poor-risk (age-adjusted international prognostic index at 2–3) CD20+ diffuse larg...
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Article
Postoperative serum proteomic profiles may predict metastatic relapse in high-risk primary breast cancer patients receiving adjuvant chemotherapy
A total of 30–50% of early breast cancer (EBC) patients considered as high risk using standard prognostic factors develop metastatic recurrence despite standard adjuvant systemic treatment. A means to better p...
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Article
Early administration of recombinant erythropoietin improves hemoglobin recovery after reduced intensity conditioned allogeneic stem cell transplantation
The use of recombinant human erythropoietin (rHuEPO) has been controversial after myeloablative allogeneic Stem cell transplantation (allo-SCT). Reduced intensity conditioning regimens (RIC) offer a novel appr...
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Article
Postoperative serum proteomic profiles and identification of biomarkers with prognosis value in high-risk early breast cancer patients
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Article
Graft-versus-myeloma effect following antithymocyte globulin-based reduced intensity conditioning allogeneic stem cell transplantation
In all, 41 multiple myeloma (MM) patients received an antithymocyte globulin (ATG), fludarabine, and busulfan-based reduced intensity conditioning (RIC) for allogeneic stem cell transplantation (allo-SCT) from...
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Article
Multivariate analysis of survival in inflammatory breast cancer: impact of intensity of chemotherapy in multimodality treatment
The prognosis of inflammatory breast cancer (IBC) is poor. We evaluated clinical and biopathological characteristics that could affect survival in 74 women with nonmetastatic IBC consecutively treated in our i...
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Article
Les mesures de la qualité de vie en cancérologie peuvent-elles hanger la pratique des cliniciens?
Les mesures de la qualité de vie sont susceptibles de modifier la pratique des cliniciens impliqués dans le domaine du cancer, car elles les aident à choisir un traitement ou une procédure médicale en prenant ...
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Article
Les banques de tissus tumoraux appliquées au cancer du sein : pourquoi? Comment?
L’hétérogénéité des tumeurs est un concept aujourd’hui bien établi en oncologie médicale. La reconnaissance de cette hétérogénéité implique une prise en charge multidisciplinaire de la maladie, et une caractér...
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Article
Traitement précoce de l’anémie, en cours de chimiothérapie, par érythropoïétine : qu’attendre d’un schéma simplifié? À propos de l’expérience de l’Institut Paoli Calmettes-Marseille
La fatigue et l’anémie sont les symptômes les plus fréquemment rapportés par les patients en cours de chimiothérapie. Les traitements curatifs sont souvent d’une efficacité retardée et insuffisante, et ont un ...
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Article
Autologous stem cell transplantation for acute myelogenous leukemia in first complete remission: a 6-year follow-up study of 101 patients from a single institution
The objective of the study was to assess the long-term outcome and impact of stem cell source in patients with acute myelogenous leukemia (AML) who received ASCT in first complete remission (CR). A total of 10...
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Article
Occult tumor cell contamination in patients with stage II/III breast cancer receiving sequential high-dose chemotherapy
The purpose of this study was to evaluate the presence of micrometastatic cells in the apheresis products from patients with breast cancer, and also to determine if repeated infusion of contaminated products h...
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Article
Infectious complications following allogeneic HLA-identical sibling transplantation with antithymocyte globulin-based reduced intensity preparative regimen
In the setting of reduced-intensity conditioning (RIC) regimens for allogeneic stem cell transplantation (allo-SCT), the epidemiology of transplant-related infections is still poorly defined. In 101 high-risk ...
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Article
Higher doses of CD34+ peripheral blood stem cells are associated with increased mortality from chronic graft-versus-host disease after allogeneic HLA-identical sibling transplantation
Allogeneic peripheral blood stem cell transplantation (PBSCT) has emerged as an alternative to bone marrow transplantation. PBSCT can be associated with a higher incidence of chronic graft-versus-host disease ...
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Article
Cost–effectiveness of repeated aphereses in poor mobilizers undergoing high-dose chemotherapy and autologous hematopoietic cell transplantation
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Chapter and Conference Paper
Feasibility of High Dose Melphalan (140 mg/m2) and Peripheral Blood Stem Cell Support as Consolidation for Patients over 60 Years with Acute Myeloid Leukemia in First Complete Remission
The optimal post remission treatment of acute myeloid leukemia(AML) in patients over 60years remains controversial and is regularly disappointing This is explained by a higher incidence of adverse prognostic f...
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Article
Intensive sequential dose dense chemotherapy with stem cell support as first-line treatment in advanced ovarian carcinoma: a phase II study
From August 1995 to December 1997, 15 patients with stage III–IV ovarian cancer were treated with outpatient intensive chemotherapy with G-CSF and stem cell support. The first cycle consisted of cyclophophamid...
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Article
Features of large granular lymphocytes (LGL) expansion following allogeneic stem cell transplantation: a long-term analysis
Large granular lymphocyte (LGL) proliferation typically follows a chronic course during which major features are cytopenia and immune abnormalities. Elevated numbers of LGL were reported in a few cases followi...
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Article
Modulations of dose intensity of doxorubicin and cyclophosphamide in association with G-CSF and peripheral blood stem cells in adjuvant chemotherapy for breast cancer: comparative evaluation of completion and safety of three intensive regimens
The aim of this study was to evaluate and to compare in terms of toxicity the modulations of dose intensity of cyclophosphamide and doxorubicin in adjuvant chemotherapy for high-risk breast cancer. Four cycles...
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Article
Overexpression of erb B2 remains a major risk factor in non-metastatic breast cancers treated with high-dose alkylating agents and autologous stem cell transplantation
The importance of dose intensity has been strongly emphasized in high-risk breast cancer. Overexpression of erb B2 is clearly correlated with an overall poor prognosis which could be limited in patients receiv...
