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  1. Article

    Open Access

    Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells

    Cancer cells are characterized by the Warburg effect, a shift from mitochondrial respiration to oxidative glycolysis. We report here the crucial role of cyclin D1 in promoting this effect in a cyclin-dependent...

    M. Caillot, J. Bourgeais, H. Dakik, É. Costé, N. M. Mazure, É. Lelièvre… in Oncogenesis (2020)

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  2. Article

    Open Access

    The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A

    Amifostine (WR-2721, delivered as Ethyol®) is a phosphorylated aminothiol compound clinically used in addition to cis-platinum to reduce the toxic side effects of therapeutic treatment on normal cells without red...

    S Dedieu, X Canron, HR Rezvani, M Bouchecareilh, F Mazurier, R Sinisi… in BMC Medicine (2010)

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  3. No Access

    Article

    Successful therapeutic effect in a mouse model of erythropoietic protoporphyria by partial genetic correction and fluorescence-based selection of hematopoietic cells

    Erythropoietic protoporphyria is characterized clinically by skin photosensitivity and biochemically by a ferrochelatase deficiency resulting in an excessive accumulation of photoreactive protoporphyrin in ery...

    A Fontanellas, M Mendez, F Mazurier, M Cario-André, S Navarro, C Ged… in Gene Therapy (2001)

  4. No Access

    Article

    Rapid analysis and efficient selection of human transduced primitive hematopoietic cells using the humanized S65T green fluorescent protein

    We have developed an efficient and rapid method to analyze transduction in human hematopoietic cells and to select them. We constructed two retroviral vectors using the recombinant humanized S65T green fluores...

    F Mazurier, F Moreau-Gaudry, V Maguer-Satta, S Salesse… in Gene Therapy (1998)

  5. No Access

    Article

    Gene transfer of the uroporphyrinogen III synthase cDNA into haematopoietic progenitor cells in view of a future gene therapy in congenital erythropoietic porphyria

    Congenital erythropoietic porphyria (CEP) is an inherited metabolic disorder characterized by an overproduction and accumulation of porphyrins in bone marrow. This autosomal recessive disease results from a de...

    F. Mazurier, F. Moreau-Gaudry, S. Salesse… in Journal of Inherited Metabolic Disease (1997)

  6. No Access

    Article

    Correction of the enzyme deficit of bone marrow cells in congenital erythropoietic porphyria by retroviral gene transfer

    F. Moreau-Gaudry, C. Barbot, F. Mazurier, F. X. Mahon… in Hematology and Cell Therapy (1996)