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Article
Factors affecting both peripheral blood progenitor cell mobilization and hematopoietic recovery following autologous blood progenitor cell transplantation in multiple myeloma patients: a monocentric study
The aim of the study was to analyze the factors influencing peripheral blood progenitor cell (PBPC) collection after high-dose cyclophosphamide (HDCYC) (7 g/m2) and hematopoietic recovery after autologous transpl...
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Chapter and Conference Paper
Autologous Stem Cell Transplantation for Chronic Myeloid Leukemia
Autologous stem cell transplantation (ASCT) has been used in chronic myeloid leukemia (CML) for the past 20 years. ASCT was first proposed in CML in transformation with the objective of achieving a second chro...
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Article
Age-adapted induction treatment of acute lymphoblastic leukemia in the elderly and assessment of maintenance with interferon combined with chemotherapy. A multicentric prospective study in forty patients
Acute lymphoblastic leukemia (ALL) in the elderly is characterized by its poor prognosis. Forty patients with ALL, aged 55 years or older, and with good performance status (ECOG <3) were prospectively treated ...
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Chapter and Conference Paper
Peripheral Blood Stem Cell Transplantation in Acute Myeloid Leukemia
Autologous peripheral blood stem cell (PBSC) transplantation was first successfully performed in patients with acute myelogenous leukemia (AML) during the mid 1980s. Since these reports [1-3], the number of pa...
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Chapter and Conference Paper
Adult Acute Lymphoblastic Leukemia — Results of the French AALL 87 Protocol with Different Strategies of Postremission Therapy
If complete remission (CR) is now obtained in close to 80% of cases, with intensified induction chemotherapy [1, 2, 3], in adult acute lymphoblastic leukemia (ALL) preventive treatments of relapse is still con...
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Chapter and Conference Paper
Is Early Response to Chemotherapy a Useful Prognostic Factor in Adult Acute Lymphoblastic Leukemia
In order to assess the eventual prognostic significance of early response to chemotherapy in adult acute lymphoblastic leukemia (ALL), we recommended to perform a bone marrow aspiration at day 15 after the beg...
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Chapter and Conference Paper
Possible Effect of Autologous Blood Stem Cell Transplantation on Outcome of Acute Myeloid Leukemia in First Relapse
Despite recent progress in the treatment of acute myelogenous leukemia (AML), most patients who achieve complete remission (CR) relapse within 2 years following induction chemotherapy. In some of these latter ...
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Article
Peripheral neuropathies and lymphoma without monoclonal gammopathy: a new classification
Recent progress in immunopathological studies of peripheral nerve and lymph node fragments together with 16 personal cases and numerous clinicopathological reports have suggested a new classification of periph...
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Chapter and Conference Paper
Treatment of Relapsed or Refractory Acute Leukemia: Comparison of Two Different Regimens
The treatment of relapsed or refractory acute leukemia (AL) remains problematic. The use of high-dose cytosine arabinoside (HD Ara-C) appears promising [1] and its association with M-amsacrine (M-AMSA) has ach...
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Chapter and Conference Paper
Comparison of Chemotherapy and Autologous and Allogeneic Transplantation as Postinduction Regimen in Adult Acute Lymphoblastic Leukemia: a Preliminary Multicentric Study
The results of chemotherapy in adults with acute lymphoblastic leukemia (ALL) have improved in recent years but have lagged behind those in children with ALL [1, 2]. The overall probability of achieving comple...
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Chapter and Conference Paper
Incomplete Stroma Formation by Bone Marrow from Chronic Myeloid Leukemia Patients Treated with Interferon
Chronic myeloid leukemia (CML) results from the neoplastic transformation of a pluripotent stem cell. The disease is characterized by a significantly increased number of granulo-monocytic progenitors in both t...
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Article
Uncompacted myelin lamellae in two cases of peripheral neuropathy
Peripheral nerve biopsies from two patients with chronic sensorimotor neuropathy were studied. The first case was a non-Hodgkin malignant lymphoma and did not show any dysglobulinemia. The second case had a be...
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Article
Gene dosage effect for human triosephosphate isomerase and glyceraldehyde-3-phosphate dehydrogenase in partial trisomy 12p13 and trisomy 18p
An 8-year-old girl with profound mental retardation and a neurologic syndrome associated with morphologic abnormalities was found to have a supernumerary small submetacentric chromosome. Several members of her...
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Article
Pericentric inversion and partial monosomy 4q associated with congenital anomalies
A case of complex structural rearrangement of chromosome 4 identified by R-banding as 46,XX,del(4),inv(4)(pter→16::q24→p16::q32→qter) is reported in an infant with congenital anomalies and psychomotor retardat...