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Article
Selective depletion of marrow-T cytotoxic lymphocytes (CD8) in the prevention of graft-versus-host disease after allogeneic bone-marrow transplantation
In vitro depletion of mature pan-T lymphocytes has been widely and successfully used to prevent acute graft-versus-host disease (GVHD) after allogeneic bone-marrow transplantation (BMT). However, this procedur...
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Chapter and Conference Paper
Treatment of Relapsed or Refractory Acute Leukemia: Comparison of Two Different Regimens
The treatment of relapsed or refractory acute leukemia (AL) remains problematic. The use of high-dose cytosine arabinoside (HD Ara-C) appears promising [1] and its association with M-amsacrine (M-AMSA) has ach...
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Chapter and Conference Paper
Incomplete Stroma Formation by Bone Marrow from Chronic Myeloid Leukemia Patients Treated with Interferon
Chronic myeloid leukemia (CML) results from the neoplastic transformation of a pluripotent stem cell. The disease is characterized by a significantly increased number of granulo-monocytic progenitors in both t...
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Chapter
Purged Autologous Bone Marrow: Better or Worse than Circulating Stem Cells?
Autologous bone marrow tranplantation (ABMT) has been extensively used as treatment for hematological malignancies over the last decade [1]. The main cause of failure after ABMT is relapse or recurrence of the...
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Article
Anti-LFA1 monoclonal antibody (25.3) for treatment of steroid-resistant grade III–IV acute graft-versus-host disease
The in vivo efficacy of 25.3 monoclonal antibody (mAb) directed against human LFA1 molecule was assessed in ten patients with steroid-resistant grade III–IV acute graft-versus-host disease (AGVHD). These patie...
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Chapter and Conference Paper
Possible Effect of Autologous Blood Stem Cell Transplantation on Outcome of Acute Myeloid Leukemia in First Relapse
Despite recent progress in the treatment of acute myelogenous leukemia (AML), most patients who achieve complete remission (CR) relapse within 2 years following induction chemotherapy. In some of these latter ...
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Chapter and Conference Paper
Prospective Study Comparing Idarubicin and Daunorubicin in Elderly Patients with Acute Myeloid Leukemia
There is general agreement about the use of a combination of cytosine arabinoside (Ara-C) and anthracycline as induction chemotherapy for patients with acute myeloid leukemia (AML). Cytosine arabinoside is usu...
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Chapter and Conference Paper
Use of Recombinant Interleukin-2 (RU 49637) After Autologous Bone Marrow Transplantation in Patients with Hematological Disease: Phase I–II Study
Allogeneic bone marrow transplantation (BMT) is currently an established therapy for hematological malignancies. Twenty years of experience has demonstrated that curability comes from both tumor ablation due t...
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Chapter and Conference Paper
Treatment of Relapsed Acute Myeloid Leukemia with Granulocyte-Macrophage Colony-Stimulating Factor and Intensive Chemotherapy
The treatment of relapsed acute myeloid leukemia (AM L) often involves the use of high-dose cytosine arabinoside (ara-C) [10]. The combination of ara-C and amsacrine gives good results [3], permitting a comple...
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Chapter and Conference Paper
Toxicity Profile of Idarubicin: Experiences with Oral and Intravenous Idarubicin in the Treatment of Leukemia
Idarubicin (IDR) is a new potent antileukemic agent and the only anthracycline derivative in current use that can be administered orally. We review here the French experience with oral and IV IDR.
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Chapter and Conference Paper
The In Vitro Effect of Interferon-γ on Chronic Myeloid Leukemia Cells
Chronic myeloid leukemia (CM L) results from the neoplastic transformation of a pluripotent hematopoietic stem cell [1]. At present the only curative treatment for this disease is an allogeneic bone marrow tra...
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Chapter and Conference Paper
Bone Marrow Transplantation for Chronic Myeloid Leukemia in France. Results of the French Cooperative Group
Transplants were performed in 281 patients (pts) with chronic myeloid leukemia (CML) in France between 1979 and 1986. The actuarial survival after 5 years is 55% for the patients receiving grafts in first chro...
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Chapter
The Use of Long-Term Culture Techniques to Study Peripheral Blood Stem Cells Before and After Autologous Transplantation
Autologous blood stem cells collected during the recovery phase after intensive chemotherapy are rich in progenitor cells, and, when infused into patients who have received myeloablative therapy, lead to rapid...
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Chapter and Conference Paper
Recombinant Human Erythropoietin After Bone Marrow Transplantation — A Placebo Controlled Trial
Several historically controlled studies [1,3,5] and one small open prospective randomized trial [4] showed an acceleration of erythropoietic recon-stitution after allogeneic bone marrow transplantation (BMT). ...
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Chapter and Conference Paper
IL2 in Acute Leukemia
Immunotherapy is a logical approach for the strategy of a currative treatment for acute leukemia since allogeneic bone marrow transplantation had demonstrated the benefit of graft versus host disease (GVHD) to...
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Article
Correction of the enzyme deficit of bone marrow cells in congenital erythropoietic porphyria by retroviral gene transfer
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Article
Blood cell transplantation: past, present and future
Blood cell transplantation is rapidly replacing bone marrow transplantation for restoration of hematopoiesis after high-dose chemotherapy in both the autologous and allogeneic settings. Future developments of ...
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Chapter and Conference Paper
Peripheral Blood Stem Cell Transplantation in Acute Myeloid Leukemia
Autologous peripheral blood stem cell (PBSC) transplantation was first successfully performed in patients with acute myelogenous leukemia (AML) during the mid 1980s. Since these reports [1-3], the number of pa...
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Chapter and Conference Paper
Allogeneic and Autologous Bone Marrow Transplantation and Chemotherapy in First Remission of Adult Acute Lymphoblastic Leukemia: Results of the LALA 87 Trial of the French Group
In a prospective study of 317 acute lymphoblastic leukemia (ALL) patients aged 15–40 years and in complete remission, 257 had a potential donor and one HLA ty** analysis; A total of 116 patients were allocat...
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Article
Plasma cytokines in graft vs host disease and complications following bone marrow transplantation
A cohort of 201 autologous or allogeneic bone marrow transplanted (BMT) patients were included for studying the evolution of circulating tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) by mean...