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Open AccessReporting practices of pharmacodynamic studies involving invasive research procedures in cancer trials
Tumour biopsy for pharmacodynamic (PD) study is increasingly common in early-phase cancer trials. As they are non-diagnostic, the ethical justification for such procedures rests on their knowledge value. On th...
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Article
Open AccessA phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas
Standard cytotoxic treatments for neuroendocrine tumours have been associated with limited activity and remarkable toxicity. A phase II study was designed to evaluate the efficacy, safety and pharmacodynamics ...
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Article
A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial
Background/Patients and methods: 16 adult patients with untreated measurable locally advanced or metastatic inoperable soft tissue sarcoma were treated with oral perifosine, a synthetic a...
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Article
Open AccessPhase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
Erlotinib (Tarceva™, OSI-774), a potent epidermal growth factor receptor tyrosine kinase inhibitor (EGFR), was evaluated in a phase II study to assess its activity in patients with metastatic colorectal cancer...
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Article
Open AccessA phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common malignant tumour, which has a poor prognosis. Surgical resection can be curative but most patients are inoperable and most chemotherapy agents have minimal activity i...
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Cancer Drugs and Cancer Drug Development for the New Millennium
Most chemotherapeutic agents used today were identified by empirically screening natural products or synthetic compounds for cytotoxic potency in vitro against murine and/or human cancer cell lines and in vivo...
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Article
The psychosocial impact of bone marrow transplantation: a review of the literature
Bone marrow transplant (BMT) is a procedure used for the treatment of a variety of cancers and malignant diseases. Recovery from this intensive process requires a long-term course, often accompanied by acute m...
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Article
A multicentre phase II study of carboplatin and prolonged oral etoposide in the treatment of cancer of unknown primary site (CUPS)
Cisplatin-based combination chemotherapy is frequently used to treat patients with carcinoma of unknown primary site (CUPS). Response rates in the literature range from 12% to 26% and median survival from 5 to...
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Article
Quality of life scores: An independent prognostic variable in a general population of cancer patients receiving chemotherapy
This report examines the prognostic associations between QOL scores measured by the EORTC QLQ-C30 and survival in a large heterogeneous population of cancer patients. Eight hundred and fifty-one cancer patient...
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Article
Current perspectives on camptothecins in cancer treatment
The camptothecins are a new class of chemotherapeutic agents which have a novel mechanism of action targeting the nuclear enzyme topoisomerase I. Knowledge of the structure-activity relationships of the parent...