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Open AccessShift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade
To determine the most relevant pathogens for CAP in Germany, patients with radiologically confirmed pulmonary infiltrates and at least one clinical sign of lung infection were prospectively recruited within th...
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Tumor und Zysten in der Lunge: Läuse, Flöhe oder beides?
Eine 60-jährige Patientin mit insulinpflichtigem Diabetes stellt sich mit Husten, thorakalen Schmerzen und subfebrilen Temperaturen vor. Die Diagnostik ergibt ein pulmonales Adenokarzinom. Außerdem werden bipu...
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Open AccessPolymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia
The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect outcome and toxicity in childhood acute lymp...
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How I treat …
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Tumor und Zysten in der Lunge – Läuse, Flöhe oder beides?
In diesem Artikel wird über eine 60-jährige Patientin mit insulinpflichtigem Diabetes berichtet, die sich mit Husten, thorakalen Schmerzen und subfebrilen Temperaturen vorstellt. Im Auskultationsbefund ist bei...
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Pulmonale infektiöse Komplikationen rheumatischer Erkrankungen
Bei der Behandlung rheumatischer Erkrankungen stellen Infektkomplikationen ein wesentliches klinisches Problem dar. Eine Steigerung der Infektionsrate resultiert im Wesentlichen aus der immunsuppressiven Thera...
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Labormedizin in der Pneumologie
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Ambulant erworbene Pneumonie
Eine rationale Diagnostik der ambulant erworbenen Pneumonie soll dem Arzt helfen, eine definitive Diagnose zu stellen, den verantwortlichen Erreger zu bestimmen und eine Aussage über die Prognose zu treffen. „...
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Open AccessA phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common malignant tumour, which has a poor prognosis. Surgical resection can be curative but most patients are inoperable and most chemotherapy agents have minimal activity i...
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Die koronare Herzerkrankung — eine entzündliche oder infektiöse Krankheit?
Die Beteiligung eines entzündlichen Prozesses an der Pathogenese der Arteriosklerose ist mittlerweile anerkannt, obwohl eine kausale Beziehung zu einem bestimmten Agens noch nicht gefunden werden konnte. Eine ...
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Coronary artery disease: an inflammatory or infectious process
It is well accepted that coronary artery disease is linked to an inflammatory process. It is unknown which agents may cause or accelerate coronary artery disease. An inflammation of the vessel wall may be cau...
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1,25-Dihydroxycholecalciferol Stimulates ICAM-1 Expression of Human Alveolar Macrophages in Healthy Controls and Patients with Sarcoidosis
Synthesis and release of 1,25-dihydroxycholecalciferol (1,25-(OH)2D2) by alveolar macrophages (AM) have been shown to be increased in granulomatous lung disease. ICAM-1 plays a major part in leukocyte homing to ...
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Impaired neutrophil exocytosis in patients with severe pneumonia
Objective: Polymorphonuclear neutrophils (PMN) are one of the major effector cells of pulmonary defence against bacterial infection. To determine whether neutrophil function is impaired ...
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Immunsuppressive Therapie bei interstitiellen Lungenerkrankungen und immunologisch vermittelten Pneumonitiden
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Production of reactive oxygen species by central venous and arterial neutrophils in severe pneumonia and cardiac lung edema
Objective: In pneumonia the influx of neutrophils to the lungs is thought to be of primary importance with regard to host defence and to complications like the adult respiratory distress...
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Free Papers
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FatalAspergillus pericarditis in acquired immunodeficiency syndrome
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Sustained cough in methotrexate therapy for rheumatoid arthritis
Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associat...
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Fas (CD95) expression on CD4+ T cells from HIV-infected patients increases with disease progression
Active T cell suicide (apoptosis) is supposed to be involved in the CD4+ T cell depletion in the course of HIV infection. We investigated the expression of the apoptosis-related antigen Fas on CD4+ T cells from 2...
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Pharmacokinetics of paroxetine in patients with cirrhosis
In a 14-day multiple-dose study the pharmacokinetics of paroxetine was investigated in 12 patients with alcoholic cirrhosis and in 6 subjects without liver disease. The dose of 20–30 mg paroxetine daily was ad...
