Skip to main content

8 Result(s)

within T Skovsgaard Remove this filter

and

  1. Article

    Open Access

    A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is a common malignant tumour, which has a poor prognosis. Surgical resection can be curative but most patients are inoperable and most chemotherapy agents have minimal activity i...

    K Dalhoff, J Dancey, L Astrup, T Skovsgaard, K J Hamberg… in British Journal of Cancer (2003)

    Download PDF (123 KB) View Article

  2. No Access

    Article

    P-glycoprotein expression in Ehrlich ascites tumour cells after in vitro and in vivo selection with daunorubicin

    Fluctuation analysis experiments were performed to assess whether selection or induction determines expression of P-glycoprotein and resistance in the murine Ehrlich ascites tumour cell line (EHR2) after expos...

    D Nielsen, J Eriksen, C Maare, AH Jakobsen, T Skovsgaard in British Journal of Cancer (1998)

  3. No Access

    Article

    Transport of the multidrug resistance modulators verapamil and azidopine in wild type and daunorubicin resistant Ehrlich ascites tumour cells

    Verapamil has been proposed to modulate the multidrug resistance phenotype by competitive inhibition of an energy dependent efflux of cytotoxic drug. However, the accumulation of both 14C-verapamil and 3H-vera...

    M Sehested, T Skovsgaard, P Buhl Jensen, EJF Demant, E Friche… in British Journal of Cancer (1990)

  4. No Access

    Article

    In vitro evaluation of the potential of aclarubicin in the treatment of small cell carcinoma of the lung (SCCL)

    The sensitivity of eight cell lines established from treated and untreated patients with small cell carcinoma of the lung (SCCL) was tested in the clonogenic assay with 1 h and continuous exposure to aclarubic...

    PB Jensen, L Vindeløv, H Roed, EJF Demant, M Sehested… in British Journal of Cancer (1989)

  5. No Access

    Article

    Inhibition of vincristine binding to plasma membrane vesicles from daunorubicin-resistant Ehrlich ascites cells by multidrug resistance modulators

    The multidrug resistance (MDR) phenotype is presumed to be mostly dependent on changes in the resistant cell plasma membrane, notably the emergence of a 170 kDa glycoprotein called P-glycoprotein, which facili...

    M Sehested, P Buhl Jensen, T Skovsgaard, N Bindslev… in British Journal of Cancer (1989)

  6. No Access

    Article

    Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil

    Numerous studies have indicated that the plasma membrane plays an important role in the development of resistance to anthracycline and vinca alkaloid drugs (pleiotropic resistance). We have previously shown th...

    M Sehested, T Skovsgaard, B van Deurs, H Winther-Nielsen in British Journal of Cancer (1987)

  7. No Access

    Article

    Cross resistance and cellular uptake of 4′-O-methyldoxorubicin in experimental tumors with acquired resistance to doxorubicin

    A new analog of doxorubicin, 4′-O-methyldoxorubicin, was previously reported to have a pronounced activity agianst L1210 leukemia, which shows a natural partial resistance to doxorubicin itself. In the present...

    A. Di Marco, T. Skovsgaard, A. M. Casazza… in Cancer Chemotherapy and Pharmacology (1981)

  8. No Access

    Article

    In vitro and in vivo study of cross resistance between daunorubicin and daunorubicin-DNA complex in Ehrlich ascites tumor

    The antitumor effect of daunorubicin and of two preparations of daunorubicin-DNA complexes were compared in equitoxic doses against the Ehrlich ascites tumor and in a subline of this tumor resistant to daunoru...

    T. Skovsgaard in Cancer Chemotherapy and Pharmacology (1979)