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Article
Metabolites from Smilax nantoensis with Antioxidant Activity
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Article
Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autophagy in Retinal Pigment Epithelial Cells
Chronic hyperglycemia involves persistent high-glucose exposure and correlates with retinal degeneration. It causes various diseases, including diabetic retinopathy (DR), a major cause of adult vision loss. Mo...
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Article
Open AccessExosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in the survival of an organism. This communication occurs by different methods, one of which is extracellular vesicles. ...
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Article
The effect of carboxymethyl cellulose and β-cyclodextrin as debittering agents on bitterness and physicochemical properties of bitter gourd extract
Bitter gourd extract (BGE) is rich in antioxidants and anti-diabetic components that promote good human health; however, its bitter taste makes it challenging to use in food. In this study, the effect of carbo...
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Article
Antioxidant Activity of Cinnamomum osmophloeum
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Biocompatibility, Bio-Clearance, and Toxicology
Biomaterials’ biocompatibility has been a highly contentious topic for years. The phenomenon’s definite significance and underlying mechanisms of biomaterials still need to be discovered. The ability of a biom...
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Article
Open AccessNovel fusion peptide‐mediated siRNA delivery using self‐assembled nanocomplex
Gene silencing using siRNA can be a new potent strategy to treat many incurable diseases at the genetic level, including cancer and viral infections. Treatments using siRNA essentially requires an efficient an...
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Article
Superhydrophobic/superoleophilic corn straw as an eco-friendly oil sorbent for the removal of spilled oil
Here, a distinctive eco-friendly corn straw material with preferable superhydrophobicity and superoleophilicity for separating oil from liquid mixtures is proposed. The raw corn straw was successfully modified...
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Article
Concentration of Docosahexaenoic and Eicosapentaenoic Acid from Cobia Liver Oil by Acetone Fractionation of Fatty Acid Salts
The production of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) concentrate from cobia liver oil by acetone fractionation of fatty acid salts was investigated in this study. A three-level-three-fa...
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Article
Optimally Fabricated Chitosan Particles Containing Ovalbumin Induced Cellular and Humoral Immunity in Immunized Mice
Subunit vaccines have been developed as promising vaccines with safety. However, subunit vaccines have difficulties in commercialization due to low efficiencies of delivery and immune response. As a result, st...
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Article
Open AccessSulforaphene inhibits esophageal cancer progression via suppressing SCD and CDH3 expression, and activating the GADD45B-MAP2K3-p38-p53 feedback loop
Esophageal cancer is one of the most common cancer with limited therapeutic strategies, thus it is important to develop more effective strategies to against it. Sulforaphene (SFE), an isothiocyanate isolated f...
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Article
Hydrolysis of Orange Peel with Cellulase and Pectinase to Produce Bacterial Cellulose using Gluconacetobacter xylinus
Oranges (Citrus sinensis) are the world’s most processed fruit. The waste from processing is rich in soluble sugars, cellulose, hemicelluloses and pectin and therefore has potential as feedstock for bacterial cel...
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Article
Open AccessIridium-based probe for luminescent nitric oxide monitoring in live cells
Nitric oxide (NO) is an intra- and extracellular messenger with important functions during human physiology process. A long-lived luminescent iridium(III) complex probe 1 has been designed and synthesized for the...
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Article
Synergistic Transdermal Delivery of Biomacromolecules Using Sonophoresis after Microneedle Treatment
Transdermal drug delivery systems have been studied as an attractive alternative to conventional delivery routes. However, the outermost layer of the skin, the stratum corneum, acts as a primary barrier to dru...
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Article
The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression
Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, t...
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Article
Open AccessMarine-derived protein kinase inhibitors for neuroinflammatory diseases
Neuroinflammation is primarily characterized by overexpression of proinflammatory mediators produced by glial activation or immune cell infiltration. Several kinases have been shown to be critical mediators in...
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Article
Open AccessDual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells
2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinoline-11-one (BPIQ), is a synthetic quinoline analog. A previous study showed the anti-cancer potential of BPIQ thr...
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Article
Optimization of High Solids Dilute Acid Hydrolysis of Spent Coffee Ground at Mild Temperature for Enzymatic Saccharification and Microbial Oil Fermentation
Soluble coffee, being one of the world’s most popular consuming drinks, produces a considerable amount of spent coffee ground (SCG) along with its production. The SCG could function as a potential lignocellulo...
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Article
Open AccessInhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability
Trans-ferulic (FA) acid exhibits antioxidant effects in vitro. However, the underlying mechanism of trans-FA activity in cellular physiology, especially cancer physiology, remains larg...
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Article
Open AccessContributions of p38 and ERK to the antinociceptive effects of TGF-β1 in chronic constriction injury-induced neuropathic rats
Transforming growth factor-βs (TGF-βs) are a group of multifunctional proteins that have neuroprotective roles in various experimental models. We previously reported that intrathecal (i.t.) injections of TGF-β...
