-
Article
Open AccessKDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges
Breast cancer (BC) is the most frequent malignant cancer diagnosis and is a primary factor for cancer deaths in women. The clinical subtypes of BC include estrogen receptor (ER) positive, progesterone receptor...
-
Article
Open AccessExosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in the survival of an organism. This communication occurs by different methods, one of which is extracellular vesicles. ...
-
Article
Synthesis and luminescence monitoring of iridium(III) complex-functionalized gold nanoparticles and their application for determination of gold(III) ions
A new method is presented for the one-step synthesis and real-time monitoring of iridium(III) complex-functionalized AuNPs from the precursor gold(III) chloride (AuCl3). The functionalized AuNPs with an average s...
-
Article
Open AccessHomocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
In hypoxia and hyperglycemia, SET7/9 plays an important role in controlling HIF-1α methylation and regulating the transcription of HIF-1α target genes, which are responsible for angiogenesis and wound healing....
-
Article
Open AccessA small molecule HIF-1α stabilizer that accelerates diabetic wound healing
Impaired wound healing and ulcer complications are a leading cause of death in diabetic patients. In this study, we report the design and synthesis of a cyclometalated iridium(III) metal complex 1a as a stabilize...
-
Article
Open AccessThe emerging role of KDM5A in human cancer
Histone methylation is a key posttranslational modification of chromatin, and its dysregulation affects a wide array of nuclear activities including the maintenance of genome integrity, transcriptional regulat...
-
Article
Open AccessCorrection to: The design and development of covalent protein-protein interaction inhibitors for cancer treatment
An amendment to this paper has been published and can be accessed via the original article.
-
Article
Open AccessThe design and development of covalent protein-protein interaction inhibitors for cancer treatment
Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibiti...
-
Article
Rebalancing metal dyshomeostasis for Alzheimer’s disease therapy
Alzheimer’s disease (AD) is a type of neurodegenerative malady that is associated with the accumulation of amyloid plaques. Metal ions are critical for the development and upkeep of brain activity, but metal d...
-
Article
Silver nanoclusters functionalized with Ce(III) ions are a viable “turn-on-off” fluorescent probe for sulfide
The authors show that silver nanoclusters functionalized with Ce(III) ions are a viable fluorescent probe for selective and sensitive detection of sulfide at pH 7.0. The blue fluorescence of silver nanocluster...
-
Article
Open AccessIridium-based probe for luminescent nitric oxide monitoring in live cells
Nitric oxide (NO) is an intra- and extracellular messenger with important functions during human physiology process. A long-lived luminescent iridium(III) complex probe 1 has been designed and synthesized for the...
-
Article
Group 8–9 Metal-Based Luminescent Chemosensors for Protein Biomarker Detection
The development of transition metal complex-based luminescent chemosensors has recently aroused increasing interest for protein biomarker labelling and detection, especially for the real-time diagnosis and tre...
-
Article
Open AccessTurn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform
A sensitive turn-on luminescent sensor for H2O2 based on the silver nanoparticle (AgNP)-mediated quenching of an luminescent Ir(III) complex (Ir-1) has been designed. In the absence of H2O2, the luminescence inte...
-
Article
Open AccessLuminescent turn-on detection of Hg(II) via the quenching of an iridium(III) complex by Hg(II)-mediated silver nanoparticles
A novel luminescent turn-on detection method for Hg(II) was developed. The method was based on the silver nanoparticle (AgNP)-mediated quenching of Ir(III) complex 1. The addition of Hg(II) ions causes the lumine...
-
Article
Open AccessAnticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction
The hypoxia inducible factor (HIF) pathway has been considered to be an attractive anti-cancer target. One strategy to inhibit HIF activity is through the disruption of the HIF-1α–p300 protein-protein interact...
-
Article
Open AccessA cyclometalated iridium(III) complex used as a conductor for the electrochemical sensing of IFN-γ
A novel iridium(III) complex was prepared and used as a conductor for sensitive and enzyme-free electrochemical detection of interferon gamma (IFN-γ). This assay is based on a dual signal amplification mechani...
-
Article
Open AccessPlatycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells
AKT is the frequently overexpressed and constitutively active kinase within NSCLC cells and recognized as a promising target for NSCLC treatment. However, AKT inhibition relieves the feedback inhibition of ups...
-
Article
Open AccessAntagonizing STAT5B dimerization with an osmium complex
Targeting STAT5 is an appealing therapeutic strategy for the treatment of hematologic malignancies and inflammation. Here, we present the novel osmium(II) complex 1 as the first metal-based inhibitor of STAT5B di...
-
Article
Open AccessAn Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells
A long-lived aldol reaction-based iridium(III) chemosensor [Ir(ppy)2(5-CHOphen)]PF6 (1, where ppy = 2-phenylpyridine and 5-CHOphen = 1,10-phenanthroline-5-carbaldehyde) for proline detection has been synthesized....
-
Article
Open AccessApplication of iridium(III) complex in label-free and non-enzymatic electrochemical detection of hydrogen peroxide based on a novel “on-off-on” switch platform
We herein report a label-free and non-enzymatic electrochemical sensor for the highly sensitive detection of hydrogen peroxide (H2O2) based on a novel “on-off-on” switch system. In our design, MB was used as an e...
