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Article
Open AccessTargeted Hsp70 fluorescence molecular endoscopy detects dysplasia in Barrett’s esophagus
The incidence of esophageal adenocarcinoma (EAC) has been increasing for decades without significant improvements in treatment. Barrett’s esophagus (BE) is best established risk factor for EAC, but current sur...
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Article
Open AccessPromising potential of [177Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy—a preclinical study using a syngeneic breast cancer model
It was previously demonstrated that radiation effects can enhance the therapy outcome of immune checkpoint inhibitors. In this study, a syngeneic breast tumor mouse model was used to investigate the effect of [17...
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Article
Open AccessNotch signaling drives development of Barrett’s metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa
Barrett’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC), but its cellular origin and mechanism of neoplastic progression remain unresolved. Notch signaling, which plays a key role in regulat...
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Article
Open AccessInhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability
Trans-ferulic (FA) acid exhibits antioxidant effects in vitro. However, the underlying mechanism of trans-FA activity in cellular physiology, especially cancer physiology, remains larg...
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Role of Tumour-Associated Macrophages in the Regulation of Angiogenesis
As mentioned in previous chapters, tumours consist not only of malignant cells but also of various stromal cell types including tumour-associated macrophages (TAMs) (Sica et al. 2008). One early sign that TAMs...
