11 Result(s)
within
Hans-Jürgen Seyfarth
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Article
Open AccessAssociation of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis
Animal experiments and early phase human trials suggest that inhibition of factor XIa (FXIa) safely prevents venous thromboembolism (VTE), and specific murine models of sepsis have shown potential efficacy in ...
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Article
Open AccessGene panel diagnostics reveals new pathogenic variants in pulmonary arterial hypertension
A genetic predisposition can lead to the rare disease pulmonary arterial hypertension (PAH). Most mutations have been identified in the gene BMPR2 in heritable PAH. However, as of today 15 further PAH genes have ...
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Article
Open AccessMonotherapy in patients with pulmonary arterial hypertension at four German PH centres
Although combination therapy is the gold standard for patients with pulmonary arterial hypertension (PAH), some of these patients are still being treated with monotherapy.
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Article
Open AccessTemporarily switching from oral to intravenous selexipag in patients with pulmonary arterial hypertension: safety, tolerability, and pharmacokinetic results from an open-label, phase III study
The oral IP receptor agonist selexipag is approved for the long-term treatment of pulmonary arterial hypertension (PAH). Treatment interruptions should be avoided due to the progressive nature of the disease. ...
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Article
Open AccessTobacco-smoking induced GPR15-expressing T cells in blood do not indicate pulmonary damage
Recently, it was shown that chronic tobacco smoking evokes specific cellular and molecular changes in white blood cells by an excess of G protein-coupled receptor 15 (GPR15)-expressing T cells as well as a hyp...
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Open AccessLate outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study
Acute pulmonary embolism (PE) is a frequent cause of death and serious disability. The risk of PE-associated mortality and morbidity extends far beyond the acute phase of the disease. In earlier follow-up stud...
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Article
MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH
Besides the established biomarker NT-proBNP, the new cardiovascular biomarkers MR-proANP, MR-proADM, Copeptin, and CT-proET-1 are promising to evaluate hemodynamics, exercise parameters, and prognosis in pati...
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Open AccessNasal High-flow versus non-invasive ventilation in stable hypercapnic COPD: a preliminary report
There are no data available about effectiveness of Nasal High-flow (NHF)in chronic respiratory insufficiency.
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Open AccessAnxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
The objective of this prospective study was to assess the prevalence of anxiety and depression disorders and their association with quality of life (QoL), clinical parameters and survival in patients with pulm...
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Article
Exercise Capacity Affects Quality of Life in Patients with Pulmonary Hypertension
The objective of this prospective study was to evaluate the impact of exercise capacity, mental disorders, and hemodynamics on quality-of-life (QoL) parameters in patients with pulmonary arterial hypertension ...
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Article
Open AccessExercise training in pulmonary arterial hypertension associated with connective tissue diseases
The objective of this prospective study was to assess short- and long-term efficacy of exercise training (ET) as add-on to medical therapy in patients with connective tissue disease-associated pulmonary arteri...
