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Article
Geschlechterspezifische Aspekte kardiovaskulärer Erkrankungen
Kardiovaskuläre Erkrankungen sind weltweit sowohl bei Männern als auch bei Frauen die führende Todesursache. Durch fokussierte klinische und wissenschaftliche Untersuchungen hat sich das Verständnis für geschl...
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Article
Open AccessHereditäre pulmonal-arterielle Hypertonie
Die hereditäre pulmonal-arterielle Hypertonie (PAH) kann durch Mutation in mindestens 18 Genen ausgelöst werden. Das am häufigsten veränderte Gen ist das für den „bone morphogenetic protein receptor 2“ (BMPR2). A...
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Article
Open AccessOral Treprostinil is Associated with Improved Survival in FREEDOM-EV and its Open-Label Extension
In the event-driven FREEDOM-EV trial, oral treprostinil delayed clinical worsening in patients with pulmonary arterial hypertension (PAH). Open-label extension studies offer additional data about tolerability,...
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Article
Open AccessSafety and effectiveness of standardized exercise training in patients with pulmonary hypertension associated with heart failure with preserved ejection fraction (TRAIN-HFpEF-PH): study protocol for a randomized controlled multicenter trial
Left heart failure (HF) is characterized by an elevation in left-sided filling pressures, causing symptoms of dyspnea, impairing exercise capacity, and leading to pulmonary venous congestion and secondary pulm...
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Article
Open AccessHypochromic red cells as a prognostic indicator of survival among patients with systemic sclerosis screened for pulmonary hypertension
Patients with systemic sclerosis (SSc) are frequently affected by iron deficiency, particularly those with pulmonary hypertension (PH). The first data indicate the prognostic importance of hypochromic red cell...
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Article
Open AccessOxygenated hemoglobin as prognostic marker among patients with systemic sclerosis screened for pulmonary hypertension
Oxygenated hemoglobin (OxyHem) in arterial blood may reflect disease severity in patients with systemic sclerosis (SSc). The aim of this study was to analyze the predictive value of OxyHem in SSc patients scre...
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Article
Open AccessTolerability, safety and survival in patients with severe pulmonary arterial hypertension treated with intravenous epoprostenol (Veletri®): a prospective, 6-months, open label, observational, non-interventional study
Epoprostenol AS (Veletri®), a thermostable epoprostenol formulation, provides better drug stability and improved clinical use compared to previous epoprostenol formulations. This study aims to expand clinical exp...
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Open AccessThe effect of exercise training and physiotherapy on left and right heart function in heart failure with preserved ejection fraction: a systematic literature review
The impact of exercise training and physiotherapy on heart function and pulmonary circulation parameters in heart failure with preserved ejection fraction (HFpEF) patients is uncertain. Hence, we performed a s...
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Article
Open AccessDiagnostic accuracy of automated 3D volumetry of cardiac chambers by CT pulmonary angiography for identification of pulmonary hypertension due to left heart disease
To assess diagnostic accuracy of automated 3D volumetry of cardiac chambers based on computed tomography pulmonary angiography (CTPA) for the differentiation of pulmonary hypertension due to left heart disease...
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Article
Open AccessPrognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis
The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulm...
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Article
Open AccessGene panel diagnostics reveals new pathogenic variants in pulmonary arterial hypertension
A genetic predisposition can lead to the rare disease pulmonary arterial hypertension (PAH). Most mutations have been identified in the gene BMPR2 in heritable PAH. However, as of today 15 further PAH genes have ...
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Article
Age-changes in right ventricular function–pulmonary circulation coupling: from pediatric to adult stage in 1899 healthy subjects. The RIGHT Heart International NETwork (RIGHT-NET)
The present study analyzes age-specific changes in RV function and RV–PA coupling in a large cohort of apparently healthy subjects with a wide age-range, to identify reference values and to study the influence...
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Article
Open AccessPrognostic impact of hypochromic erythrocytes in patients with pulmonary arterial hypertension
Iron deficiency affects up to 50% of patients with pulmonary arterial hypertension (PAH) but iron markers such as ferritin and serum iron are confounded by several non-disease related factors like acute inflam...
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Article
Feasibility of semi-recumbent bicycle exercise Doppler echocardiography for the evaluation of the right heart and pulmonary circulation unit in different clinical conditions: the RIGHT heart international NETwork (RIGHT-NET)
Exercise Doppler echocardiography (EDE) is a well-validated tool in ischemic and valvular heart diseases. However, its use in the assessment of the right heart and pulmonary circulation unit (RH-PCU) is limite...
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Article
Open AccessA multicentric quality-control study of exercise Doppler echocardiography of the right heart and the pulmonary circulation. The RIGHT Heart International NETwork (RIGHT-NET)
This study was a quality-control study of resting and exercise Doppler echocardiography (EDE) variables measured by 19 echocardiography laboratories with proven experience participating in the RIGHT Heart Inte...
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Article
Author Correction: NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessAuthor Correction: Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and death worldwide. Peroxynitrite, formed from nitric oxide, which is derived from inducible nitric oxide synthase, and superoxide, h...
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Article
Open AccessRisk stratification and prognostic factors in patients with pulmonary arterial hypertension and comorbidities a cross-sectional cohort study with survival follow-up
The objective of this study was to analyze prognostic factors and risk stratification in patients with pulmonary arterial hypertension (PAH) and comorbidities.
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Article
Open AccessTherapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are comp...