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Article
Open AccessTwo single lung transplantations from one donor: lung twinning in the LAS era
The implementation of the Lung Allocation Score (LAS) in the Eurotransplant international collaborative framework decreased waiting list mortality, but organ shortage remains a significant problem. Transplanta...
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Article
Open AccessMachine learning assisted feature identification and prediction of hemodynamic endpoints using computed tomography in patients with CTEPH
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but potentially curable cause of pulmonary hypertension (PH). Currently PH is diagnosed by right heart catheterisation. Computed tomography (CT) ...
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Article
Kommentar zu den Leitlinien (2022) der ESC/ERS zur Diagnostik und Behandlung der pulmonalen Hypertonie
Die pulmonale Hypertonie (PH) ist ein häufiges Phänomen, das bei ca. 1 % der Bevölkerung auftritt und das unabhängig von der zugrunde liegenden Ursache mit einer erheblichen Morbidität und Mortalität einhergeh...
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Article
Open AccessOutcome of lung transplant recipients infected with SARS-CoV-2/Omicron/B.1.1.529: a Nationwide German study
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is currently the major threat for immunocompromised individuals. The course of COVID-19 in lung t...
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Article
Interventionelle Therapie und multidisziplinäre Managementstrategien für die akute Lungenembolie
Die interventionelle Therapie der akuten Lungenembolie bietet großes Potenzial zur Senkung von Morbidität und Mortalität ausgewählter Patientinnen und Patienten mit intermediär-hohem und hohem Risiko. In diese...
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Article
Open AccessYouTube-videos for patient education in lymphangioleiomyomatosis?
The Internet is commonly used by patients to acquire health information. To date, no studies have evaluated the quality of information available on YouTube regarding lymphangioleiomyomatosis (LAM). Our aim was...
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Article
The Phagocytosis of Blood Leukocytes from Cystic Fibrosis Patients is not Impaired in General
Impaired phagocytosis of Pseudomonas aeruginosa was found in isolated monocytes of peripheral blood of cystic fibrosis patients, but not in their neutrophils, as reported some years ago. In the present study, we ...
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Akute und chronische Lungenembolie
Die akute Lungenembolie ist ein häufiges Krankheitsbild, das weitreichende Konsequenzen für die betroffenen Patienten haben kann. Neben der signifikanten Gefahr einer akuten Rechtsherzdekompensation mit hoher ...
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Article
Open AccessIncidence and characteristics of chronic thromboembolic pulmonary hypertension in Germany
The incidence of chronic thromboembolic pulmonary hypertension (CTEPH) is unknown. Previous studies from the United Kingdom and Spain have reported incidence rates of 1.75 and 0.9 per million, respectively. Th...
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Article
Anxiety, Depression, and Health-Related QOL in Patients Diagnosed with PAH or CTEPH
Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are life-threatening diseases with a high burden of symptoms. Although depression, anxiety, and reduced health re...
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Article
Open AccessEfficacy and safety of nasal high-flow oxygen in COPD patients
Nasal high-flow oxygen therapy (HFOT) is a novel treatment option for patients suffering from acute or chronic respiratory failure. Aim of our study was to compare safety and efficacy of HFOT with those of con...
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Article
Open AccessLate outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study
Acute pulmonary embolism (PE) is a frequent cause of death and serious disability. The risk of PE-associated mortality and morbidity extends far beyond the acute phase of the disease. In earlier follow-up stud...
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Article
Open AccessThe role of circulating thrombospondin-1 in patients with precapillary pulmonary hypertension
The vasoconstrictive protein TSP-1 is released from endothelial cells upon increased shear stress and hypoxia. Both conditions are prevalent in pulmonary hypertension (PH). TSP-1 damages the local microcircula...
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Article
Open AccessRuntime and aPTT predict venous thrombosis and thromboembolism in patients on extracorporeal membrane oxygenation: a retrospective analysis
Even though bleeding and thromboembolic events are major complications of extracorporeal membrane oxygenation (ECMO), data on the incidence of venous thrombosis (VT) and thromboembolism (VTE) under ECMO are s...
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Article
MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH
Besides the established biomarker NT-proBNP, the new cardiovascular biomarkers MR-proANP, MR-proADM, Copeptin, and CT-proET-1 are promising to evaluate hemodynamics, exercise parameters, and prognosis in pati...
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Article
Open AccessA symptom-related monitoring program following pulmonary embolism for the early detection of CTEPH: a prospective observational registry study
Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term complication following an acute pulmonary embolism (PE). It is frequently diagnosed at advanced stages which is concerning as delayed treatm...
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Article
Economic Evaluation of Exercise Training in Patients with Pulmonary Hypertension
Exercise training as an add-on to medical therapy has been shown to improve exercise capacity, quality of life, and possibly prognosis in patients with pulmonary hypertension (PH). The purpose of this study wa...
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Article
Exercise Capacity Affects Quality of Life in Patients with Pulmonary Hypertension
The objective of this prospective study was to evaluate the impact of exercise capacity, mental disorders, and hemodynamics on quality-of-life (QoL) parameters in patients with pulmonary arterial hypertension ...
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Article
Open AccessLong-term effects of intravenous iloprost in patients with idiopathic pulmonary arterial hypertension deteriorating on non-parenteral therapy
The majority of patients with idiopathic pulmonary arterial hypertension (IPAH) in functional classes II and III are currently being treated with non-parenteral therapies, including endothelin receptor antagon...
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Article
Progrediente Dyspnoe eines Hufschmieds — EAA und rezidivierende Rauchgas-Inhalationen als seltene Ursache
Es wird ein 47-jähriger Patient mit progredienter Dyspnoe und produktivem Husten infolge einer exogen-allergischen Alveolitis beschrieben. Ätiologisch konnte diese Hypersensitivitätspneumonitis — durch Nachwei...
