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Article
Open AccessDynamic regulation of N6,2′-O-dimethyladenosine (m6Am) in obesity
The prevalent m6Am mRNA cap modification was recently identified as a valid target for removal by the human obesity gene FTO along with the previously established m6A mRNA modification. However, the deposition an...
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Article
Age-related loss of gene-to-gene transcriptional coordination among single cells
A long-standing model holds that stochastic aberrations of transcriptional regulation play a key role in the process of ageing. While transcriptional dysregulation is observed in many cell types in the form of...
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Article
Open AccessDirected evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance
Mammalian SIRT6 is a well-studied histone deacetylase that was recently shown to exhibit high protein deacylation activity enabling the removal of long chain fatty acyl groups from proteins. SIRT6 was shown to...
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Article
The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance
Dysfunction of the deacetylase Sirt1 has been associated with certain metabolic diseases. Abramson and colleagues show that Sirt1 has high expression in the thymus, where it deacetylates the transcriptional re...
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Article
Open AccessMammalian conserved ADAR targets comprise only a small fragment of the human editosome
ADAR proteins are among the most extensively studied RNA binding proteins. They bind to their target and deaminate specific adenosines to inosines. ADAR activity is essential, and the editing of a subset of th...
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Article
SIRT6, a protein with many faces
Sirtuins are NAD+ dependent deacylases enzymes. There are seven mammalian sirtuins, SIRT1–SIRT7, which are localized to different cellular compartments and are capable of diverse catalytic activities. SIRT6 is a ...
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Article
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
Nematodes define a new role for sirtuins in lifespan extension, in which the sirtuin product nicotinamide is converted to a substrate for aldehyde oxidase; turnover of this enzyme generates hydrogen peroxide, ...
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Article
The sirtuin SIRT6 regulates lifespan in male mice
The role of sirtuins in longevity is controversial, and little is known about mammalian sirtuins; now, male mice that overexpress SIRT6 are shown to have a longer lifespan than wild-type mice, unlike their fem...
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Article
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of...
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Chapter
Metabolic Regulation of Gene Silencing and Life Span
The timing of gene expression defines the particular activity of a single cell or tissue and ensures the proper development of the organism. In higher eukaryotes most genes are “silent,” meaning that they are ...
