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  1. Article

    Erratum: Sirtuins — novel therapeutic targets to treat age-associated diseases

    Nature Reviews Drug Discovery 7, 841–853 (2008) | doi:10.1038/nrd2665 The structure of suramin on page 844 is incorrect; the correct structure is shown below: The following paragraph and associated reference w...

    Siva Lavu, Olivier Boss, Peter J. Elliott… in Nature Reviews Drug Discovery (2009)

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  2. Article

    Open Access

    Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

    Calorie restriction (CR) produces a number of health benefits and ameliorates diseases of aging such as type 2 diabetes. The components of the pathways downstream of CR may provide intervention points for deve...

    Jesse J Smith, Renée Deehan Kenney, David J Gagne, Brian P Frushour… in BMC Systems Biology (2009)

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    Article

    Sirtuins — novel therapeutic targets to treat age-associated diseases

  4. Sirtuins (SIRTs) are NAD-dependent deacetylases that have a central role in regulating the cellular proteins and their physiological pathways. Interest in ther...

    5. Siva Lavu, Olivier Boss, Peter J. Elliott… in Nature Reviews Drug Discovery (2008)

  5. No Access

    Article

    Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

    SIRT1, an NAD+-dependent deacetylase that acts on proteins involved in cellular regulation, has been implicated in longevity and as a mediator of the beneficial effects of calorie restriction. A new screening pro...

    Jill C. Milne, Philip D. Lambert, Simon Schenk, David P. Carney, Jesse J. Smith… in Nature (2007)

  6. Article

    Correction: Corrigendum: Sirtuin activators mimic caloric restriction and delay ageing in metazoans

    Nature 430, 686–689 (2004). There are errors in Fig. 4 of this Letter: panels a and d are correct; however, panel c was incorrectly published as a duplicate of panel a, and panel b should have been labelled as...

    Jason G. Wood, Blanka Rogina, Siva Lavu, Konrad Howitz, Stephen L. Helfand… in Nature (2004)

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    Article

    Sirtuin activators mimic caloric restriction and delay ageing in metazoans

    Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases2,3. Sirtui...

    Jason G. Wood, Blanka Rogina, Siva Lavu, Konrad Howitz, Stephen L. Helfand… in Nature (2004)

  8. No Access

    Article

    Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

    In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of...

    Konrad T. Howitz, Kevin J. Bitterman, Haim Y. Cohen, Dudley W. Lamming, Siva Lavu… in Nature (2003)