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  1. No Access

    Article

    Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

    In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of...

    Konrad T. Howitz, Kevin J. Bitterman, Haim Y. Cohen, Dudley W. Lamming, Siva Lavu… in Nature (2003)

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    Article

    Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

    Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals. Numerous hypotheses have been proposed to explain this phenomenon, including decreased oxidative damage and altered e...

    Rozalyn M. Anderson, Kevin J. Bitterman, Jason G. Wood, Oliver Medvedik… in Nature (2003)

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    Chapter

    Metabolic Regulation of Gene Silencing and Life Span

    The timing of gene expression defines the particular activity of a single cell or tissue and ensures the proper development of the organism. In higher eukaryotes most genes are “silent,” meaning that they are ...

    Haim Y. Cohen, Kevin J. Bitterman, David A. Sinclair in Aging at the Molecular Level (2003)