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Article
Open AccessBranched-chain amino acid catabolism is a conserved regulator of physiological ageing
Ageing has been defined as a global decline in physiological function depending on both environmental and genetic factors. Here we identify gene transcripts that are similarly regulated during physiological ag...
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Article
Open AccessD-Glucosamine supplementation extends life span of nematodes and of ageing mice
D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independe.....
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Article
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
Nematodes define a new role for sirtuins in lifespan extension, in which the sirtuin product nicotinamide is converted to a substrate for aldehyde oxidase; turnover of this enzyme generates hydrogen peroxide, ...
