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Article
Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy
Conventional cancer treatment methods suffer from many limitations such as non-specificity and low efficacy in discrimination between healthy and cancer cells. Recent developments in nanotechnology have intro...
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Article
Neural tissue regeneration by a gabapentin-loaded cellulose acetate/gelatin wet-electrospun scaffold
In the present study, gabapentin (GBP), an anticonvulsant drug used as an analgesic to control the neuropathic pains, was incorporated with cellulose acetate (CA) and gelatin (Gel) in order to develop a potent...
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Article
Sciatic nerve regeneration by using collagen type I hydrogel containing naringin
In the present study, collagen hydrogel containing naringin was fabricated, characterized and used as the scaffold for peripheral nerve damage treatment. The collagen was dissolved in acetic acid, naringin add...
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Article
A de novo theranostic nanomedicine composed of PEGylated graphene oxide and gold nanoparticles for cancer therapy
A de novo drug delivery nanosystem based on gold nanoparticles (GNPs), decorated poly(ethylene glycol) (PEG), and folate (FA)-conjugated graphene oxide (GO) was designed and developed successfully. Initially, ...
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Article
A promising wound dressing based on alginate hydrogels containing vitamin D3 cross-linked by calcium carbonate/d-glucono-δ-lactone
In the present study, we fabricated vitamin D3-loaded alginate hydrogel and assessed its wound healing capability in the animal model. The various concentrations of vitamin D3 were added to the pre-dissolved sodi...
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Article
Open AccessElectrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies
Functional wound dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/Ge...
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Article
Conducting polymer-based electrically conductive adhesive materials: design, fabrication, properties, and applications
In the past few decades, increasing demands for electrically conductive adhesives (ECAs) have led to growing interest in the design and development of innovative strategies to obtain materials with synergetic ...
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Article
Open AccessA tailored polylactic acid/polycaprolactone biodegradable and bioactive 3D porous scaffold containing gelatin nanofibers and Taurine for bone regeneration
The focus of the current study was to develop a functional and bioactive scaffold through the combination of 3D polylactic acid (PLA)/polycaprolactone (PCL) with gelatin nanofibers (GNFs) and Taurine (Tau) for...
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Article
Open AccessHuman plasma protein corona decreases the toxicity of pillar-layer metal organic framework
This scenario was designed to investigate the protein corona pattern on the pillar-layer surface of a Cu-based metal–organic framework (MOF) in human plasma. The [Cu(L)(L/)].1.3DMA (MOF-1) {L = 4, 4/-bipyridine a...
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Article
Open AccessOsteoconductive and electroactive carbon nanofibers/hydroxyapatite nanocomposite tailored for bone tissue engineering: in vitro and in vivo studies
In this study, we aimed to fabricate osteoconductive electrospun carbon nanofibers (CNFs) decorated with hydroxyapatite (HA) crystal to be used as the bone tissue engineering scaffold in the animal model. CNFs...
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Article
Electrically Conductive Nanofibers Composed of Chitosan-grafted Polythiophene and Poly(ε-caprolactone) as Tissue Engineering Scaffold
Two novel electrically conductive nanofibrous scaffolds based on chitosan-grafted polythiophene (CS-g-PTh), and chitosan-grafted polythiophene/poly(ε-caprolactone) (CS-g-PTh/PCL) have been fabricated through elec...
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Article
Multi-stimuli-responsive magnetic hydrogel based on Tragacanth gum as a de novo nanosystem for targeted chemo/hyperthermia treatment of cancer
A novel magnetic pH- and redox-responsive drug delivery system (DDS) based on natural Tragacanth gum (TG) was developed for targeted chemo/hyperthermia treatment of cancer. Firstly, acrylic acid (AA) monomer w...
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Article
Open AccessPseudohomogeneous metallic catalyst based on tungstate-decorated amphiphilic carbon quantum dots for selective oxidative scission of alkenes to aldehyde
Herein, we present an interesting role of tungstate-decorated amphiphilic carbon quantum dots (A-CQDs/W) in the selective oxidative cleavage of alkenes to aldehydes. In this work, for the first time, we disclo...
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Article
Open AccessCo-electrospun nanofibrous mats loaded with bitter gourd (Momordica charantia) extract as the wound dressing materials: in vitro and in vivo study
Interactive dressings are innovatively designed to interact with the wound surface and alter the wound environment to promote wound healing. In the current study, we integrated the physicochemical properties o...
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Article
Open AccessTarkhineh as a new microencapsulation matrix improves the quality and sensory characteristics of probiotic Lactococcus lactis KUMS-T18 enriched potato chips
In the present study, probiotic potato chips containing a newly isolated probiotic Lactococcus lactis KUMS-T18 strain were produced by using a simple spraying method and then enhancing the stability, survival rat...
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Article
Open AccessBioengineered 3D nanocomposite based on gold nanoparticles and gelatin nanofibers for bone regeneration: in vitro and in vivo study
The main aim of the present study was to fabricate 3D scaffold based on poly (l-lactic acid) (PLLA)/Polycaprolactone (PCL) matrix polymer containing gelatin nanofibers (GNFs) and gold nanoparticles (AuNPs) as the...
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Article
Mesoporous silica coated gold nanorods: a multifunctional theranostic platform for radiotherapy and X-ray imaging
The development of theranostic nanostructures is one of the most advanced branches of pharmaceutical and medical sciences in the world today. Due to the unique properties such as surface plasmon resonance, Ram...
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Article
Electroactive nanofibrous scaffold based on polythiophene for bone tissue engineering application
Electrically conductive polymeric biomaterials are promising candidates for bone tissue engineering (TE) due to pivotal role of electrical stimulation (ES) in regulating of some biological functions, including...
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Article
Plasmonic hyperthermia or radiofrequency electric field hyperthermia of cancerous cells through green-synthesized curcumin-coated gold nanoparticles
Nanoparticle-mediated hyperthermia is one of the prominent adjuvant therapies which has been faced by many problematic challenges such as efficiency and safety. To compare the nanoparticle-mediated phototherma...
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Article
Open AccessFabrication and examination of polyorganophosphazene/polycaprolactone-based scaffold with degradation, in vitro and in vivo behaviors suitable for tissue engineering applications
The present study aimed to synthesis a proper scaffold consisting of hydroxylated polyphosphazene and polycaprolactone (PCL), focusing on its potential use in tissue engineering applications. The first graftin...
