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Article
Rosa canina extract relieves methylation alterations of pancreatic genes in STZ-induced diabetic rats
Diabetes is a chronic metabolic disease that affects many parts of the body. Considering diabetes as a beta cells’ defect and loss, the focus is on finding mechanisms and compounds involved in stimulating the ...
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Article
Preparation and Evaluation of Extended-Release Nanofibers Loaded with Pramipexole as a Novel Oral Drug Delivery System: Hybridization of Hydrophilic and Hydrophobic Polymers
Pramipexole (Prami) is renowned as one of the most widely used drugs in the treatment of Parkinson’s disease. This study aimed to prepare slow-release nanofibers of Prami to reduce (or control) the release rat...
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Article
Targeting Common Signaling Pathways for the Treatment of Stroke and Alzheimer’s: a Comprehensive Review
Neurodegenerative diseases such as stroke and Alzheimer’s disease (AD) are two inter-related disorders that affect the neurons in the brain and central nervous system. Alzheimer’s is a disease by undefined ori...
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Article
Open AccessCo-electrospun nanofibrous mats loaded with bitter gourd (Momordica charantia) extract as the wound dressing materials: in vitro and in vivo study
Interactive dressings are innovatively designed to interact with the wound surface and alter the wound environment to promote wound healing. In the current study, we integrated the physicochemical properties o...
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Article
Anti-diabetic effect of a novel oligosaccharide isolated from Rosa canina via modulation of DNA methylation in Streptozotocin-diabetic rats
Diabetes mellitus (DM) is a well-known clinical entity with various late complications. There is a surge of research aiming to use the medical herb in the management of DM.
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Article
Genetics of intellectual disability in consanguineous families
Autosomal recessive (AR) gene defects are the leading genetic cause of intellectual disability (ID) in countries with frequent parental consanguinity, which account for about 1/7th of the world population. Yet...
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Article
Study of gene expression and steviol glycosides accumulation in Stevia rebaudiana Bertoni under various mannitol concentrations
Stevia rebaudiana produces sweet steviol glycosides that are 300 times sweeter than sugar and have the beneficial effects on human health including anti-hyperglycaemic. Tissue culture is the best method with high...
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Article
Comparison of correlation ranking and eigenvalue ranking unfolded principal component regression for direct determination of naproxen in human serum using excitation–emission matrix fluorescence spectroscopy
Using principal components as input of a multivariate calibration model always brings up the question what subset of PCs gives the best reliable regression model with the most predictability. In this current s...
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Article
Rapid separation of human globin chains in normal and thalassemia patients by RP-HPLC
The present study describes a rapid and sensitive high-performance liquid chromatography (HPLC) method for the detection of human globin chains in blood. The method involves direct injection of globin chains w...
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Article
The Xmn1 polymorphic site 5′ to the Gγ gene and its correlation to the Gγ:Aγ ratio, age at first blood transfusion and clinical features in β-Thalassemia patients from Western Iran
β-Thalassemia is the most common single gene disorder in Iran and more than 25,000 affected individuals have been reported. It has been reported that in patients with β-thalassemia in the presence of Xmn1 polymor...
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Article
Quantitative Analysis of Sertraline in Human Serum by LC with Fluorescence Detection After Pre-Column Derivatization with 4-Chloro-7-nitrobenzofurazan
An accurate and sensitive reversed-phase high-performance liquid chromatographic method for analysis of sertraline in human serum, using 4-chloro-7-nitrobenzofurazan as pre-column derivatization agent, is desc...
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Article
Co-existence of fatty acids changes in aorta artery and adipose tissue; comparison between CAD and non CAD patients
Background This study was aimed to evaluate composition and possible co-existence of change in fatty acids of aorta artery and adipose tissue in two groups of patients with different degr...
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Article
Enhancement of Fluorescence Intensity of Tramadol and Its Main Metabolites in LC Using Pre-Column Derivatization with 9-Fluorenylmethyl Chloroformate
Tramadol was found to exhibit weak fluorescence with a maximum emission at 300 nm when excited at 200 nm. Also, fluorescence spectra of the drug and its two main metabolites, O-desmethyltramadol and N-desmethyltr...
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Article
Preparation of a Novel Iodide-Selective Electrode Based on Iodide-Miconazole Ion-Pair and Its Application to Pharmaceutical Analysis
An iodide-miconazole ion-paired complex was used as a suitable ion-exchanger for the preparation of a plasticized-PVC membrane electrode. Among different solvent mediators tested, dioctylsebacate exhibited the...
