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Article
ProPSA and the Prostate Health Index as predictive markers for aggressiveness in low-risk prostate cancer—results from an international multicenter study
One of the major challenges in prostate cancer (PCa) treatment is distinguishing insignificant PCa from those forms that need active treatment. We evaluated the impact of PSA isoforms on risk stratification in...
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Article
Open AccessPIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer
Novel drugs like Abiraterone or Enzalutamide, which target androgen receptor (AR) signaling to improve androgen deprivation therapy (ADT), have been developed during the past years. However, the application of...
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Article
Open AccessEpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205
Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpC...
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Article
[-2]proPSA is an early marker for prostate cancer aggressiveness
The aim of the study was to evaluate the correlation between preoperative [-2]proPSA, the Gleason Score (GS) and the risk of non-organ-confined (NOC) disease in patients undergoing radical prostatectomy (RP).
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Article
Open AccessDistinct ERG rearrangement prevalence in prostate cancer: higher frequency in young age and in low PSA prostate cancer
The TMPRSS2-ERG gene fusion resulting in ERG overexpression has been found in around 50% of prostate cancers (PCa) and is a very early event in tumorigenesis. Most studies have reported on selected surgical cohor...
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Article
Long-term biochemical evaluation of the androgen receptor pathway in males with disorders of sex development
Disorders of sex (DSD) development represent a serious condition. Most of the underlying mechanisms remain unclear. Disturbances within the androgen receptor (AR) pathway frequently account for 46 XY-DSDs. The...
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Article
Open AccessInsulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer
Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis. We describe how dynamic a...
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Article
Erratum: Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptor
Correction to: Cancer Gene Therapy (2002) 9, 117–125; doi:10.1038/sj.cgt.7700416 The authors have noticed an error in the ‘Materials and methods’ section, where the sequence of the antisense ODNas750/15 target...
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Article
Mechanismen der Kontrolle des Tonus der glatten Muskulatur der Prostata und ihre potentielle Bedeutung für die Pharmakotherapie des benignen Prostatasyndroms
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Article
Hot plane strain compression testing of aluminum alloys by channel-die compression
A thoroughly tested, high-temperature channel-die compression (CDC) rig is described for simulating hot plane strain compression of metallic alloys up to 500 °C. The equipment is currently used to characterize...
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Article
Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer
Background: The type IV collagenases/gelatinases matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) play an important role in cancer invasion and metastasis. In the present study, we measured the expression of ...
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Article
Dihydrotestosteron und die Rolle der 5α-Reduktasehemmer bei der benignen Prostatahyperplasie
Die Entstehung der benignen Prostatahyperplasie (BPH) beruht auf 2 Faktoren: den testikulären Androgenen und dem Alterungsprozess. Das wichtigste Androgen in der Prostata ist das Dihydrotestosteron (DHT). Beim...
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Article
Dihydrotestosterone and the concept of 5α-reductase inhibition in human benign prostatic hyperplasia
The development of human benign prostatic hyperplasia (BPH) clearly requires a combination of testicular androgens and the ageing process. Although the role of androgens as the causative factor for human beni...
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Article
Androgen receptor – an update of mechanisms of action in prostate cancer
Androgen receptor (AR), a key nuclear transcription factor in the prostate gland, is expressed in all histological types and stages of prostate cancer. The AR regulates proliferation of prostate cancer cells ...
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Article
Open AccessAndrogen receptor protein is down-regulated by basic fibroblast growth factor in prostate cancer cells
Interactions between polypeptide growth factors and the androgen receptor (AR) are important for regulation of cellular events in carcinoma of the prostate. Basic fibroblast growth factor (bFGF), the prototype...
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Article
Open AccessSwitch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system
Advanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to investigate the mechanisms relevant to the development of therapy-resistant tumours, we establish...
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Article
Interleukin 1β mediates the modulatory effects of monocytes on LNCaP human prostate cancer cells
Proliferative and secretory responses in androgen-sensitive prostate cancer LNCaP cells are regulated by steroid and peptide hormones and by differentiation-promoting substances. In the present study, we evalu...
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Article
Amphiregulin is expressed in primary cultures of prostate myofibroblasts, fibroblasts, epithelial cells, and in prostate tissue
The effect and expression of amphiregulin, a growth factor of the EGF-system was investigated in prostate primary cell cultures and in human prostate tissue. Amphiregulin increases proliferation in primary cul...
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Article
Expression of transforming growth factors beta-1, beta 2 and beta 3 in human bladder carcinomas
We previously detected elevated transforming growth factor beta-1 (TGF-beta1) serum levels in patients with invasive bladder carcinomas. In this study, we therefore investigated whether elevated serum levels c...
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Article
Activation of the androgen receptor by polypeptide growth factors and cellular regulators
The polypeptide growth factors insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), and transforming growth factor-α (TGF-α); second-messenger cyclic adenosine monophosphate (cAMP); protein kin...
