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Article
Open AccessDemonstrating the reliability of in vivo metabolomics based chemical grou**: towards best practice
While grou**/read-across is widely used to fill data gaps, chemical registration dossiers are often rejected due to weak category justifications based on structural similarity only. Metabolomics provides a r...
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Article
First-line treatment with R-CHOP or rituximab-bendamustine in patients with follicular lymphoma grade 3A—results of a retrospective analysis
Based on centroblast frequency, follicular lymphoma (FL) is subdivided into grades 1-2, 3A, and 3B. Grade FL3A frequently coexists with FL1-2 (FL1-2-3A). Based on clinical trials, FL1-2 is treated with rituxim...
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Article
Open AccessThe Importance of Consistent Global Forest Aboveground Biomass Product Validation
Several upcoming satellite missions have core science requirements to produce data for accurate forest aboveground biomass map**. Largely because of these mission datasets, the number of available biomass pr...
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Article
Open AccessConditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival
Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apopt...
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Article
Long-term follow-up of the AML97 study for patients aged 60 years and above with acute myeloid leukaemia: a study of the East German Haematology and Oncology Study Group (OSHO)
Treatment of patients (pts) with acute myelogenous leukaemia (AML) above 60 years remains a challenge. We report long-term follow-up of the AML97 study, where pts were registered at diagnosis and received trea...
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Article
CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)−mediated apoptosis
Catecholamines regulate the β -adrenoceptor/cyclic AMP-regulated protein kinase A (cAMP/PKA) pathway. Deregulation of this pathway can cause apoptotic cell death and is implicated in a range of human diseases, su...
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Article
Erfolgreiche Zertifizierung eines nichtuniversitären Onkologischen Zentrums am HELIOS Klinikum Erfurt
Ein wesentlicher Zentrumsgedanke besteht darin, dass ungeachtet des Zugangs eines Tumorpatienten jede einzelne Klinik dieses Zentrums dessen Behandlungskonzept durch ein Tumorboard festlegen lässt. Nur durch e...
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Chapter
Diagnostik
Die Diagnose einer rheumatischen Erkrankung stützt sich vordergründig auf die Anamnese und die klinischen Symptome, objektiv erhebbare Befunde wie Röntgen und Labor sind nur Ergänzungen zur Bestätigung einer V...
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Chapter
Andere Erkrankungen
Entzündliche, selten vorkommende Systemerkrankung des Knorpels mit fortschreitendem Knorpelabbau und Zerstörung anderer Bindegewebsstrukturen, als primäres Leiden eigene Entität; sekundär bei verschiedenen ent...
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Chapter
The Use of Metabolomics in Cancer Research
The use of metabolite profiling techniques (metabonomics or metabolomics) in toxicology is a relatively new branch of this science. Due to their unique biochemical properties, cancer cells should, in principle...
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Article
Biologicals in rheumatology: Austrian experiences from a rheumatic outpatient clinic
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Article
Biologicals in rheumatology: Austrian experiences from a rheumatic outpatient clinic
The efficacy of biological agents has been shown in several randomized clinical trials. However, little is known regarding the performance of these drugs in daily rheumatological care. Totally, 173 patients tr...
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Chapter and Conference Paper
Successful Treatment of a Patient with High Titer Acquired Factor VIII Inhibitor (114 BU) with Rituximab
Acquired hemophilia is a rare severe bleeding disorder caused by antibodies against coagulation factors. Factor VIII is the commonest factor affected.
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Article
Elevated levels of serum CD44 and E-cadherin predict an unfavourable outcome in myelodysplastic syndromes
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Article
Treatment of Bendamustine and Prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with Melphalan and Prednisone—a randomized phase III study of the East German Study Group of Hematology and Oncology (OSHO)
Purpose: This randomized phase III study compared bendamustine and prednisone (BP) to standard melphalan and prednisone (MP) treatment in previously untreated patients with multiple Myeloma (MM). Patients and Met...
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Article
Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin’s lymphoma and mantle cell lymphoma: results of a randomised phase III trial (OSHO# 19)
Purpose: The purpose of this study was to compare the efficacy and toxicity of bendamustine, vincristine + prednisone (BOP) with a standard regimen of cyclophosphamide, vincristine + pred...
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Article
Indirect evidence for neutralinos as dark matter
From the relic density measurement by WMAP the WIMP annihilation cross section can be determined in a model independent way. If the WIMPS are postulated to be the neutralinos of Supersymmetry, then only a limi...
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Article
Randomized phase III study for the treatment of advanced indolent non-Hodgkin's lymphomas (NHL) and mantle cell lymphoma: chemotherapy versus chemotherapy plus rituximab
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Article
Chronische lymphatische Leukämie Aktuelle Therapiekonzepte
Die chronische lymphatische Leukämie (CLL) ist die häufigste Leukämie der westlichen Welt. In den letzten 10 Jahren haben sich die Konzepte zur Therapie der CLL erheblich geändert. Neue Therapieverfahren wie P...
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Article
Costs of toxicity during chemotherapy with CHOP, COP/CVP, and fludarabine
The costs of chemotherapy toxicity were analyzed in patients with relapsed low-grade non-Hodgkin's lymphoma (NHL). A total of 91 specialists regularly treating NHL were interviewed by telephone to identify the...