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Article
Open AccessMutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy
Alterations in the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway are frequent in urothelial bladder cancer (BLCA) and thus provide a potential target for novel ...
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Article
Molecular aspects of prostate cancer
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Article
[11C]choline PET/CT in prostate cancer patients with biochemical recurrence after radical prostatectomy
To evaluate [11C]choline positron emission tomography/computed tomography ([11C]choline PET/CT) for the detection of a biochemical recurrence of prostate cancer after radical prostatectomy.
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Article
Die Rolle des Androgenrezeptors im hormonrefraktären Prostatakarzinom
Die Entstehung hormonrefraktärer Prostatakarzinomzellen während einer Hormonablationstherapie stellt die Hauptursache für den Tumorprogress und die hohe Mortalitätsrate des fortgeschrittenen Prostatakarzinoms ...
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Article
Nitric oxide-mediated inhibition of androgen receptor activity: possible implications for prostate cancer progression
Chronic inflammation increases the risk of cancer and many cancers, including prostate cancer, arise at sites of chronic inflammation. Inducible nitric oxide synthase (iNOS) is an enzyme dominantly expressed d...
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Article
Open AccessAndrogen receptor protein is down-regulated by basic fibroblast growth factor in prostate cancer cells
Interactions between polypeptide growth factors and the androgen receptor (AR) are important for regulation of cellular events in carcinoma of the prostate. Basic fibroblast growth factor (bFGF), the prototype...
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Article
Activation of the androgen receptor by polypeptide growth factors and cellular regulators
The polypeptide growth factors insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), and transforming growth factor-α (TGF-α); second-messenger cyclic adenosine monophosphate (cAMP); protein kin...
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Die Bedeutung des Onkogens HER 2 beim Ovarialkarzinom
Die Zellproliferation wird wesentlich durch zwei sich antagonisierende Gengruppen bestimmt. Dies sind zum einen die mit einer Wachstumshemmung einhergehenden Tumorsuppressorgene und zum anderen die mit einer W...